NUCLEAR UPTAKE OF SEX STEROID-HORMONES IN THE CARDIOVASCULAR-SYSTEM OF THE BABOON
NUCLEAR UPTAKE OF SEX STEROID-HORMONES IN THE CARDIOVASCULAR-SYSTEM OF THE BABOON
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DOI：
10.1161/01.res.48.2.238
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发表时间：
1981-01-01
影响因子：
20.1
通讯作者：
SHERIDAN, PJ
中科院分区：
文献类型：
--
作者：
MCGILL, HC;SHERIDAN, PJ
对6只雄性和6只雌性成年狒狒的心脏和动脉组织进行了核摄取氚化5- α的检查。-二氢睾酮（3H-DHT）或氚化雌二醇-17 - β。（3H-E2）放射自显影。3H-DHT摄取发生在大多数心房和心室心肌纤维的细胞核中，无心脏间质组织，部分动脉内皮细胞，内膜和内动脉介质的大部分平滑肌细胞和外动脉介质的少数平滑肌细胞。3H-E2摄取发生在少数心房和心室心肌纤维的细胞核、许多心脏间质细胞、偶尔的动脉内皮细胞、少数内膜和内动脉介质的平滑肌细胞、外动脉介质的平滑肌细胞和几乎所有的外动脉细胞。这些观察结果与其他放射自显影和生化结果一致，这些结果表明，一些哺乳动物物种的心脏和大动脉中含有雄激素和雌激素受体，其在肌肉和结缔组织细胞中的分布模式不同。这可能是冠心病明显的性别差异的重要原因。
Cardiac and arterial tissues of 6 male and 6 female adult baboons were examined for nuclear uptake of tritiated 5-.alpha.-dihydrotestosterone (3H-DHT) or tritiated estradiol-17.beta. (3H-E2) by autoradiography. 3H-DHT uptake occurred in nuclei of most atrial and ventricular myocardial fibers, no cardiac interstitial tissues, some arterial endothelial cells, most smooth muscle cells of the intima and inner arterial media and a few smooth muscle cells of the outer arterial media. 3H-E2 uptake occurred in nuclei of a few atrial and ventricular myocardial fibers, many cardiac interstitial cells, occasional arterial endothelial cells, a few smooth muscle cells of the intima and inner arterial media, smooth muscle cells of the outer arterial media and nearly all adventitial cells. These observations are consistent with other autoradiographic and biochemical findings which indicate that the heart and major arteries of several mammalian species contain androgen and estrogen receptors in distinctive patterns of distribution among muscle and connective tissue cells. This may be important in the apparent sex differential in coronary heart disease.