Cognitively directed spatial selection in the frontal eye field in anticipation of visual stimuli to be discriminated.
Cognitively directed spatial selection in the frontal eye field in anticipation of visual stimuli to be discriminated.
复制标题
额叶视野中的认知定向空间选择，预期要区分视觉刺激。
DOI：
10.1016/j.visres.2008.03.024
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发表时间：
2009
期刊：
影响因子：
1.8
通讯作者：
Thompson,KirkG
中科院分区：
文献类型：
--
作者：
Zhou,Hui-Hui;Thompson,KirkG
在训练完成困难的亮度辨别任务的猴子的额叶眼野（FEF）中记录单个神经元活动。提示刺激的出现告知猴子在500- 1500 ms内将出现的两个灰色亮度刺激的位置。如果猴子对两种亮度刺激中较亮的一种进行眼跳，或者如果它们是相同的亮度，则对提示刺激进行眼跳，就会得到奖励。60%（51/85）的FEF神经元表现出升高的活动时，提示通知猴子，其中一个亮度刺激将出现在他们的反应场（RF）。这种空间选择性的预期活动发生在没有任何视觉刺激出现在他们的RF和眼跳的选择或延迟。27个预期神经元（总样本的32%）的反应也不符合的假设，即活动代表眼跳概率，因为他们没有表现出升高的活动的线索刺激，这是最可能的眼跳目标。在行为上，猴子表现出改善知觉的线索比在不可预测的位置通知的位置。这些结果提供了生理学证据，FEF除了在眼跳产生中的作用外，还在内源性空间注意中起重要作用。
Single neuron activity was recorded in the frontal eye field (FEF) of monkeys trained to perform a difficult luminance discrimination task. The appearance of a cue stimulus informed the monkeys of the locations of two gray luminance stimuli that would appear within 500–1500ms. The monkeys were rewarded for making a saccade to the brighter of the two luminance stimuli, or if they were the same luminance, for making a saccade to the cue stimulus. Sixty percent (51/85) of FEF neurons exhibited elevated activity when the cue informed the monkeys that one of the luminance stimuli would appear in their response field (RF). This spatially selective anticipatory activity occurred without any visual stimulus appearing in their RF and was not related to saccade choice or latency. The responses of 27 of the anticipatory neurons (32% of the total sample) were also incompatible with the hypothesis that the activity represents saccade probability because they did not exhibit elevated activity for the cue stimulus which was the most probable saccade target. Behaviorally, monkeys exhibited improved perception at locations informed by cue than at unpredictable locations. These results provide physiological evidence that FEF serves an important role in endogenous spatial attention in addition to its well-known role in saccade production.