Crosstalk between ferroptosis and macrophages: potential value for targeted treatment in diseases
Crosstalk between ferroptosis and macrophages: potential value for targeted treatment in diseases
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DOI：
10.1007/s11010-023-04871-4
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发表时间：
2023-10
影响因子：
4.3
通讯作者：
Wanxin Lan;Lei Yang;Xuelian Tan
中科院分区：
文献类型：
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作者：
Wanxin Lan;Lei Yang;Xuelian Tan
铁凋亡是一种新发现的程序性细胞死亡形式，与铁依赖性脂质过氧化有关。它涉及多种生理过程，包括铁代谢、脂质代谢、氧化应激和烟酰胺腺嘌呤二核苷酸磷酸、谷胱甘肽和辅酶Q10的生物合成。迄今为止，已发现巨噬细胞参与了许多疾病的病理过程，如心肌梗死、急性肾损伤、动脉粥样硬化等。巨噬细胞是天然免疫系统细胞，具有调节代谢、吞噬病原体和死亡细胞、介导炎症反应、促进组织修复等作用。新出现的证据显示巨噬细胞与铁凋亡之间存在强烈的关联，为我们深入了解疾病的病理过程和治疗提供了新的靶点。本文综述了巨噬细胞与铁凋亡之间的相互作用，并分析了这种联系在疾病治疗中的应用，包括非肿瘤性和肿瘤性疾病。此外，我们还解决了一些有待研究的问题，希望能启发新的疾病治疗策略。
Ferroptosis is a newly identified form of programmed cell death that is connected to iron-dependent lipid peroxidization. It involves a variety of physiological processes involving iron metabolism, lipid metabolism, oxidative stress, and biosynthesis of nicotinamide adenine dinucleotide phosphate, glutathione, and coenzyme Q10. So far, it has been discovered to contribute to the pathological process of many diseases, such as myocardial infarction, acute kidney injury, atherosclerosis, and so on. Macrophages are innate immune system cells that regulate metabolism, phagocytize pathogens and dead cells, mediate inflammatory reactions, promote tissue repair, etc. Emerging evidence shows strong associations between macrophages and ferroptosis, which can provide us with a deeper comprehension of the pathological process of diseases and new targets for the treatments. In this review, we summarized the crosstalk between macrophages and ferroptosis and anatomized the application of this association in disease treatments, both non-neoplastic and neoplastic diseases. In addition, we have also addressed problems that remain to be investigated, in the hope of inspiring novel therapeutic strategies for diseases.