Interleukin 2 deficiency is a common feature of autoimmune mice.
Interleukin 2 deficiency is a common feature of autoimmune mice.
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白细胞介素2缺乏症是自身免疫小鼠的一个共同特征。
作者：
M. Dauphinée;S. Kipper;D. Wofsy;N. Talal
研究了自身免疫小鼠IL - 2的产生，以评估该淋巴因子在小鼠狼疮发病机制中的作用。来自自身免疫易感小鼠的脾脏和淋巴结细胞显示出产生功能性IL - 2能力的年龄依赖性丧失。这种缺陷与疾病表达相关，在MLR/Mp-Ipr/Ipr小鼠中最为严重。随着年龄的增长，MLR/Mp-Ipr/Ipr胸腺细胞逐渐失去对IL - 2的反应性。这些结果提示，自身免疫小鼠的免疫调节异常可能部分归因于IL - 2缺乏。
IL 2 production was studied in autoimmune mice to assess the role of this lymphokine in the pathogenesis of murine lupus. Spleen and lymph node cells from autoimmune-susceptible mice show an age-dependent loss in the ability to produce functional IL 2. This defect correlates with disease expression and is most severe in MLR/Mp-Ipr/Ipr mice. MLR/Mp-Ipr/Ipr thymocytes gradually lose responsiveness to IL 2 with age. These results suggest that the immunoregulatory abnormalities of autoimmune mice may be due in part to IL 2 deficiency.