PRESENCE OF ELEVATED LEVELS OF PLATELET-DERIVED GROWTH-FACTOR (PDGF) IN LUNG ADENOCARCINOMA PLEURAL EFFUSIONS
PRESENCE OF ELEVATED LEVELS OF PLATELET-DERIVED GROWTH-FACTOR (PDGF) IN LUNG ADENOCARCINOMA PLEURAL EFFUSIONS
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DOI：
10.1378/chest.102.1.204
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发表时间：
1992-07-01
期刊：
影响因子：
9.6
通讯作者：
MARTINET, Y
中科院分区：
文献类型：
--
作者：
SAFI, A;SADMI, M;MARTINET, Y
与小细胞肺癌(SCLC)相比，显著的肿瘤间质发展是肺腺癌的一个特征。肿瘤间质的纤维化成分被认为是间充质细胞因细胞因子的存在而迁移和局部复制的结果。其中，血小板衍生生长因子(PDGF)是间充质细胞的趋化生长因子。由于几种肺腺癌细胞株，而不是小细胞肺癌细胞株，在体外被证明表达PDGF基因，我们评估了肺腺癌、小细胞肺癌或非恶性胸腔积液患者胸腔积液中PDGF的存在。在肺腺癌中，胸腔积液中的PDGF水平高于小细胞肺癌和非恶性胸腔积液，并且与成纤维细胞的生长促进活性有关，部分原因是由于PDGF的存在。这一观察结果提示，PDGF在肺腺癌的肿瘤间质形成中起作用。
Significant tumor stroma development is a specific feature of adenocarcinoma of the lung in comparison to small-cell lung cancer (SCLC). The fibrotic component of tumor stroma is thought to result from the migration and local replication of mesenchymal cells in response to the presence of cytokines. One of them, platelet-derived growth factor (PDGF), is a chemotactic and growth factor for mesenchymal cells. Since several lung adenocarcinoma cell lines, but not SCLC cell lines, have been shown in vitro to express PDGF genes, we evaluated pleural effusions for the presence of PDGF in patients with adenocarcinoma of the lung, SCLC, or nonmalignant pleural effusions. In adenocarcinoma of the lung, PDGF levels in pleural effusions were higher than in SCLC and in nonmalignant pleural effusions and were associated with the presence of a growth-promoting activity for fibroblasts due, in part, to the presence of PDGF. This observation suggests the role of PDGF in tumor stroma formation in adenocarcinoma of the lung.