Molecular origins of cancer: Molecular basis of colorectal cancer.
Molecular origins of cancer: Molecular basis of colorectal cancer.
复制标题
癌症的分子起源：结直肠癌的分子基础。
DOI：
10.1056/nejmra0804588
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发表时间：
2009-12-17
期刊：
影响因子：
--
通讯作者：
Bertagnolli MM
中科院分区：
文献类型：
--
作者：
Markowitz SD;Bertagnolli MM
本文就结直肠癌分子机制的研究进展作一综述。生殖系的遗传变化，结合体细胞突变，发生在家族性结直肠癌综合征，而体细胞突变是散发性结直肠癌的突出特点。遗传变化驱动从腺瘤到癌的进展，并可能影响个体易感性和对治疗的反应。
This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.