Compromised Dynamic Cerebral Autoregulation in Patients With Depression
Compromised Dynamic Cerebral Autoregulation in Patients With Depression
复制标题
抑郁症患者的动态大脑自动调节功能受损
DOI：
10.3389/fpsyt.2019.00373
复制
发表时间：
2019-05-31
影响因子：
4.7
通讯作者：
Yang，Yi
中科院分区：
文献类型：
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作者：
Luo，Ming-Ya;Guo，Zhen-Ni;Yang，Yi
背景：抑郁症患者常伴有多种神经系统共病症状，但其机制尚不清楚。本研究的目的是分析抑郁症患者的动态脑自动调节特点。研究方法：入选年龄≥ 18岁的抑郁症患者[17项汉密尔顿抑郁量表（HAMD）> 17分]或疑似抑郁症患者（HAMD > 7分）。招募医学健康的志愿者作为对照。受试者还接受了HAMD 7项量表。我们同时记录无创连续动脉血压和双侧大脑中动脉血流速度。通过传递函数分析相位差来评估脑自动调节。结果：本研究共纳入疑似抑郁症患者54例，抑郁症患者45例，健康志愿者48例。抑郁症患者的平均相位差值显著低于正常对照组（F = 9.071，P < 0.001）。多元回归分析显示，抑郁程度与相位差值呈负相关。结论：抑郁症患者的脑动态自动调节功能受损，并与抑郁评分呈负相关。改善动态脑自动调节可能是治疗抑郁症神经症状的一种潜在治疗方法。
Background: Patients with depression tend to have various comorbid neurological symptoms, but the mechanisms remain unclear. The purpose of this study was to analyze the characteristics of dynamic cerebral autoregulation in depressed patients. Methods: Patients (aged ≥ 18 years) who were diagnosed with depression [17-item Hamilton Depression Rating Scale (HAMD) > 17] or suspected of depression (HAMD > 7) were enrolled in this study. Medically healthy volunteers were recruited as controls. The subjects also received the 7-item HAMD. We simultaneously recorded noninvasive continuous arterial blood pressure and bilateral middle cerebral artery blood flow velocity from each subject. Cerebral autoregulation was assessed by analyzing the phase difference using transfer function analysis. Results: This study enrolled 54 patients with suspected depression, 45 patients with depression, and 48 healthy volunteers. The mean phase difference values were significantly lower in the patients with depression (F = 9.071, P < 0.001). In the multiple regression analysis, depression was negatively correlated with the phase difference values. Conclusions: Dynamic cerebral autoregulation was compromised in patients with depression and negatively correlated with the depression score. Improving dynamic cerebral autoregulation may be a potential therapeutic method for treating the neurological symptoms of depression.