Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis
Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis
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DOI：
10.17219/acem/58782
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发表时间：
2017-03-01
影响因子：
2.1
通讯作者：
Ge, Zhijun
中科院分区：
文献类型：
--
作者：
Dai, Ji;Jiang, Wenjie;Ge, Zhijun
背景资料。中性粒细胞CD64(NCD64)是诊断细菌感染的有前途的标志物。有几项研究调查了nCD64在新生儿败血症诊断中的作用，结果各不相同。NCD64用于检测严重细菌感染的兴趣正在迅速增加。本研究的目的是进行荟萃分析，系统评价nCD64在新生儿败血症诊断中的准确性。据笔者所知，在此之前还没有相关研究。材料和方法。对Pubmed、Embase和Cochrane图书馆从最初到2015年6月的研究进行了回顾，发现有7项研究(涉及2213名新生儿)符合纳入标准。对7项研究进行敏感度和特异度的双变量Meta分析和汇总的受试者-操作特征(SROC)曲线；采用I-2检验异质性，通过影响分析和元回归分析异质性的来源。合并敏感性和特异性分别为80%(95%CI，69~88%)和83%(95%CI，71~90%)。SROC曲线下面积(AUC)为0.88(95%CI，0.85~0.91)。这些研究具有很大的异质性(I-2=87.1%)。结果表明，nCD64是诊断新生儿败血症的可靠标志物(AUC=0.88)。
Background. Neutrophil CD64 (nCD64) is a promising marker for diagnosing bacterial infections. Several studies have investigated the performance of nCD64 for diagnosing neonatal sepsis and the results are variable. Interest in nCD64 for detecting serious bacterial infections is increasing rapidly.Objectives. The aim of the present study was to carry out a meta-analysis to systematically evaluate the diagnostic accuracy of nCD64 in neonatal sepsis. As far as the authors know, no previous studies have undertaken this.Material and methods. A review of studies from Pubmed, Embase and the Cochrane Library, from inception through June 2015, found 7 studies (involving 2213 neonates) fulfilling the inclusion criteria. These 7 studies were subjected to a bivariate meta-analysis of sensitivity and specificity and a summary receiver-operating characteristic (SROC) curve; I-2 was used to test heterogeneity, and the source of heterogeneity was investigated by influence analysis and meta-regression.Results. The pooled sensitivity and specificity were 80% (95% CI, 69-88%) and 83% (95% CI, 71-90%), respectively. The area under the SROC curve (AUC) was 0.88 (95% CI, 0.85-0.91). The studies had substantial heterogeneity (I-2 = 87.1%).Conclusions. The results showed that nCD64 is a reliable biomarker for diagnosing neonatal sepsis (AUC = 0.88).