Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease
Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease
复制标题
脑室内注射多硫酸戊聚糖治疗变异型克雅氏病不成功
作者：
Ian R. Whittle;R. Knight;Robert G. Will
戊聚糖多硫酸酯，通过慢性脑室内输注，已被提出作为一种潜在的治疗人类朊病毒病。第一位接受治疗的患者在治疗开始后几年仍然活着。在这里，我们详细描述了变异型克雅氏病的情况下，这种治疗是在相对较早的阶段开始，但没有明确的临床效益。患者在诊断后16个月和戊聚糖多硫酸酯治疗开始后5个月死于疾病进展。
SummaryPentosan polysulphate, delivered by chronic intraventricular infusion, has been proposed as a potential therapy for human prion disease. The first treated patient is still alive several years after treatment started. Here we describe in detail a case of variant Creutzfeldt-Jakob disease in which this treatment was started at a relatively early stage but had no definite clinical benefit. The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced.