The Inflammatory Aspect of Male and Female Pattern Hair Loss.
The Inflammatory Aspect of Male and Female Pattern Hair Loss.
复制标题
DOI：
10.2147/jir.s275785
复制
发表时间：
2020
影响因子：
4.5
通讯作者：
Jimenez JJ
中科院分区：
文献类型：
--
作者：
Peyravian N;Deo S;Daunert S;Jimenez JJ
男性和女性型脱发（分别为MPHL和FPHL）是影响美国近8000万人脱发的最常见原因，但治疗选择仍然有限且缺乏。由于对更有效的治疗方法的需求仍未得到满足，这一观点提供了一个独特的角度，将注意力集中在MPHL和FPHL的炎症方面。通过对临床和定量数据的评估，强调了炎症作为MPHL和FPHL特征的证据和含义。比较结果表明，在MPHL和FPHL的表现中存在显著的滤泡周围炎性浸润，如淋巴细胞和组织细胞，以及炎症基因如CASP7和TNF的参与。MPHL和FPHL发病机制中炎症方面的重新认识将推动MPHL和FPHL治疗选择的未来发展。
Male and female pattern hair loss (MPHL and FPHL, respectively), is the most common cause of hair loss affecting nearly 80 million people in the US, yet treatment options remain limited and lacking. As the need for more effective therapeutics remains unmet, this perspective offers a unique angle by directing attention to the inflammatory aspect of MPHL and FPHL. Evidence and implications of inflammation as a characteristic feature of MPHL and FPHL are highlighted through evaluation of clinical and quantitative data. Comparable results suggest the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, as well as the involvement of inflammatory genes, such as CASP7 and TNF, in the presentation of MPHL and FPHL. Resurfacing of the inflammatory aspect in MPHL and FPHL pathogenesis will advance future developments in MPHL and FPHL therapeutic options.