CHEMOSELECTIVE GLYCOSYLATIONS .1. DIFFERENCES IN SIZE OF ANOMERIC LEAVING GROUPS CAN BE EXPLOITED IN CHEMOSELECTIVE GLYCOSYLATIONS
CHEMOSELECTIVE GLYCOSYLATIONS .1. DIFFERENCES IN SIZE OF ANOMERIC LEAVING GROUPS CAN BE EXPLOITED IN CHEMOSELECTIVE GLYCOSYLATIONS
复制标题
DOI：
10.1016/0040-4039(95)01222-4
复制
发表时间：
1995-08-28
影响因子：
1.8
通讯作者：
HOLMES, D
中科院分区：
文献类型：
--
作者：
BOONS, GJ;GEURTSEN, R;HOLMES, D
我们开发了一种新颖的化学选择性糖基化策略。这种糖基化策略基于这样一个事实，即异头巯基的糖基反应性可通过该基团的体积大小来控制，由此我们制备了一系列新的具有不同反应性的偶联底物。这种新方法将使具有生物学重要性的复杂寡糖能够以高度收敛的方式进行制备。
We have developed a novel chemoselective glycosylation strategy. This glycosylation strategy is based on the fact that the glycosyl reactivity of an anomeric thiol group can be control by the bulkiness of this group whereby we have produced a new range of differentially reactive coupling substrates. The new approach will enable complex oligosaccharides of biological importance to be prepared in a highly convergent manner.