Leukotriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs.
Leukotriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs.
复制标题
白三烯 C4 刺激离体致敏豚鼠肺中 TXA2 的形成。
DOI：
10.1016/0006-2952(81)90349-x
复制
发表时间：
1981
影响因子：
5.8
通讯作者：
Elisabeth Graström
中科院分区：
文献类型：
--
作者：
G. Folco;G. Hansson;Elisabeth Graström
白三烯构成了一组新的衍生自多不饱和脂肪酸的生物活性化合物[1 -5]。白三烯A4（LT&）是一种不稳定的环氧化物中间体，由花生四烯酸经5-羟基过氧-6，8，11，14-二十碳四烯酸形成。它可以通过水解转化为LTB 4和通过加入谷胱甘肽转化为LTCP（S（S）-羟基-6（R）&谷胱甘肽-7，9-三-ll，l-c-二十碳四烯酸）而酶促转化。LTCh在γ-谷氨酰肽酶的作用下转化为半胱氨酸衍生物（LTD 4）[6]。速发型超敏反应中的重要介质-速发型超敏反应慢反应物质（SRS-A）已被证明是由LTC 4和LTD 4引起的[5，7]。已发现SRS-A的粗品制剂刺激豚鼠肺释放血栓烷AZ（TXA 2）[8，9]。在粗SRS-A刺激后，致敏肺比正常肺释放更多的TXAZ [Q]。因此，研究化学纯的LTC 4对豚鼠肺释放血栓素的影响是有意义的。还研究了SRS-A拮抗剂（FPL 55712）对SRS-A刺激的血栓素释放的影响
The leukotrienes constitute a new group of biologically active compounds derived from polyunsaturated fatty acids [l-5]. Leukotriene A4 (LT&), an unstable epoxide intermediate, is formed from arachidonic acid via 5-hydroperoxy-6, 8, 11, 14-eicosatetraenoic acid. It can be transformed enzymatically by hydrolysis into LTB4 and by addition of glutathione into LTCP (S (S)-hydroxy-6 (R) & glutathionyl-7, 9-tr~~-ll, l~ c~-eicosatetraenoic acid). LTCh is converted into the~~ es~ nding cysteinylgly~ ine derivative (LTD4) by r_gtutamyl~~ speptidase [6]. Slow Reacting Substance of Anaphylaxis (SRS-A) which is an important mediator in immediate hypersensitivity reactions has been shown to be due to LTC4 and LTD4 [5, 7]. Crude preparations of SRS-A have been found to stimulate release of thromboxane AZ (TXA2) from guinea pig lungs [8, 9]. Sensitized lungs release more TXAZ than normal lungs following stimulation by crude SRS-A [Q]. It was therefore of interest to study the effect of chemically pure LTC4 on the release of thromboxane from guinea pig lungs. The effect of an SRS-A antagonist (FPL55712) on the SRS-A stimulated release of thromboxane was also studied