Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions
Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions
复制标题
DOI：
10.1128/jvi.79.10.6560-6564.2005
复制
发表时间：
2005-05-01
影响因子：
5.4
通讯作者：
Battini, JL
中科院分区：
文献类型：
--
作者：
Lassaux, A;Sitbon, M;Battini, JL
我们确定了新的残基内的101个氨基酸的延伸的小鼠白血病病毒衣壳，差异调节电阻和易感性的小鼠Fv1和人类Ref1基因。在这些残基中，天冬氨酸92和组氨酸117都是Fv 1（B）抗性所需的，而后者足以赋予Ref 1抗性。
We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.