Lewis and Fischer rats: a comparison of dopamine transporter and receptors levels
Lewis and Fischer rats: a comparison of dopamine transporter and receptors levels
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DOI：
10.1016/s0006-8993(98)01011-7
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发表时间：
1998-12-14
期刊：
影响因子：
2.9
通讯作者：
Srivastava, LK
中科院分区：
文献类型：
--
作者：
Flores, G;Wood, GK;Srivastava, LK
以往的报道表明，近交系大鼠Lewis(Lew)和Fischer 344(F344)在中脑边缘多巴胺(DA)功能的几个行为和生化指标上存在差异。具体地说，这两个菌株在对新环境和急性苯丙胺或可卡因挑战的行为和神经化学反应以及对成瘾的敏感性方面存在差异。为了研究DAD1样、D2样、D3受体和DA转运体的差异是否与品系间的这些行为差异有关，我们对纹状体和伏隔区域内的DA受体和转运体进行了比较放射自显影研究。我们观察到不同品系和不同地区的DA D2样受体和D3受体以及DA转运体的结合水平的差异。也就是说，LEW大鼠纹状体、伏隔核和嗅结节的DA转运体水平显著低于F344大鼠。LEW大鼠伏隔核和嗅结节壳层的DA D3密度低于F344大鼠。最后，与F344大鼠相比，LEW大鼠纹状体和伏隔核核心的D2样受体水平较低。这些数据表明，DA转运体和DA受体的差异可能在一定程度上导致了这两个菌株之间与DA相关的行为的差异。(C)1998 Elsevier Science B.V.保留所有权利。
Previous reports have shown that the inbred strains of rat, Lewis (LEW) and Fischer 344 (F344), differ in several behavioural and biochemical indices of mesolimbic dopamine (DA) function. Specifically, these two strains differ in their behavioural and neurochemical response to novel environments, and acute amphetamine or cocaine challenge as well as in their susceptibility to addiction. To investigate if differences in DA D1-like, D2-like, D3 receptors and DA transporter could be correlated with these behavioural differences between strains, a comparative autoradiographic study of DA receptors and transporter within the striatal and accumbal regions was undertaken. We observed strain and region specific differences in binding levels for DA D2-like and D3 receptors and for the DA transporter. Namely, DA transporter levels in the striatum, nucleus accumbens and olfactory tubercle of LEW rats were significantly lower than in F344 rats. DA D3 densities in the shell of the nucleus accumbens and olfactory tubercle of LEW rats were lower than the levels found in the F344 rats. Finally, LEW rats have a lower levels of D2-like receptors in the striatum and the core of the nucleus accumbens compared to F344 rats. These data suggest that differences in DA transporter and DA receptors may in part contribute to differences in DA related behaviour seen between these two strains. (C) 1998 Elsevier Science B.V. All rights reserved.