Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages1
Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages1
复制标题
肺巨噬细胞是血液单核细胞和肺泡巨噬细胞之间的必需中间体1
作者：
Limor Landsman;Steffen Jung
Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.
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影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
32.4
作者：
Kenji Takabayshi;M. Corr;Tomoko Hayashi;V. Redecke;L. Beck;D. Guiney;D. Sheppard;E. Raz
通讯作者：
Kenji Takabayshi;M. Corr;Tomoko Hayashi;V. Redecke;L. Beck;D. Guiney;D. Sheppard;E. Raz
影响因子：
2.2
作者：
Matute-Bello, G;Lee, JS;Martin, TR
通讯作者：
Martin, TR
影响因子：
4.6
作者：
Losa García JE;Rodríguez FM;Martín de Cabo MR;García Salgado MJ;Losada JP;Villarón LG;López AJ;Arellano JL
通讯作者：
Arellano JL