Oxidized-LDL/β2-Glycoprotein I Complexes Are Associated With Disease Severity and Increased Risk for Adverse Outcomes in Patients With Acute Coronary Syndromes
Oxidized-LDL/β2-Glycoprotein I Complexes Are Associated With Disease Severity and Increased Risk for Adverse Outcomes in Patients With Acute Coronary Syndromes
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DOI：
10.1309/ajcp88wvrdrdfbas
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发表时间：
2010-05-01
影响因子：
3.5
通讯作者：
Lopez, Luis R.
中科院分区：
文献类型：
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作者：
Greco, Thomas P.;Conti-Kelly, Ann Marie;Lopez, Luis R.
氧化低密度脂蛋白（oxLDL）/β 2-糖蛋白I（β 2GPI）复合物与动脉粥样硬化形成有关。对339例疑似急性冠状动脉综合征患者进行oxLDL/β 2GPI复合物测定。约68%的患者有血管造影证实的冠状动脉疾病（CAD），oxLDL/β 2GPI的平均+/- SD水平（3.75 +/- 6.31 U/mL）显著高于冠状动脉正常的患者（2.21 +/- 3.03 U/mL; P = .0026）。严重CAD患者的oxLDL/β 2GPI平均SD水平（8.71 +/- 12.87 U/mL）显著高于总体平均水平（3.25 U/mL）（P <0.05），不良事件发生率（28.9%）显著高于总体发生率（11.2%）（P <0.05）。发生不良事件的患者oxLDL/β 2GPI的平均SD水平（4.05 +/- 5.38 U/mL）高于未发生不良事件的患者（3.15 +/- 5.53; P = 0.029）。在较高oxLDL/β 2GPI四分位数中，不良事件的相对风险为3.1（95%置信区间，1.0-9.1; P = 0.06）（第3四分位数）和3.5（95%置信区间，1.2-10.4; P = 0.02）（第4四分位数）。我们的研究结果支持这样的概念，即oxLDL/β 2GPI复合物与CAD的严重程度和3.5倍的不良后果的风险增加。
Oxidized low-density lipoprotein (oxLDL)/beta(2)-glycoprotein I (beta 2GPI) complexes have been implicated in atherogenesis. oxLDL/beta 2GPI complexes were measured in 339 patients with suspected acute coronary syndromes. Approximately 68% had angiographically documented coronary artery disease (CAD) and significantly higher mean +/- SD levels of oxLDL/beta 2GPI (3.75 +/- 6.31 U/mL) than patients with normal coronary arteries (2.21 +/- 3.03 U/mL; P = .0026). Patients with severe CAD had significantly higher mean SD levels of oxLDL/beta 2GPI (8.71 +/- 12.87 U/mL) compared with the overall mean of 3.25 U/mL (P < .05) and a significantly higher rate (28.9%) of adverse events than the overall rate of 11.2% (P < .05). Patients with adverse events had higher mean SD levels of oxLDL/beta 2GPI (4.05 +/- 5.38 U/mL) than patients without adverse events (3.15 +/- 5.53; P = .029). The relative risk for adverse events in higher oxLDL/beta 2GPI quartiles was 3.1 (95% confidence interval, 1.0-9.1; P = .06) for quartile 3 and 3.5 (95% confidence interval, 1.2-10.4; P = .02) for quartile 4. Our results support the concept that oxLDL/beta 2GPI complexes are associated with severity of CAD and a 3.5-fold increased risk for adverse outcomes.