Hormonal Aspects of Ménière’s Disease on the Basis of Clinical and Experimental Studies
Hormonal Aspects of Ménière’s Disease on the Basis of Clinical and Experimental Studies
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DOI：
10.1159/000265113
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
T. Takeda;S. Takeda;A. Kakigi;T. Okada;R. Nishioka;Daizo Taguchi;M. Nishimura;H. Nakatani
中科院分区：
文献类型：
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作者：
T. Takeda;S. Takeda;A. Kakigi;T. Okada;R. Nishioka;Daizo Taguchi;M. Nishimura;H. Nakatani
结论：内耳内淋巴液的稳态被认为是由血管加压素-水通道蛋白2（VP-AQP 2）系统介导的。内淋巴积水是梅尼埃病（MD）的形态学特征，可能反映了内耳液中VP-AQP 2系统的失调。血浆血管加压素（p-VP）水平升高是MD及其相关疾病的发病因素之一。审查目的：综述VP-AQP 2系统在内耳液体稳态和内淋巴积水形成和发展中的作用。近期临床和实验研究发现：临床调查显示，p-VP水平在MD及其相关疾病中经常升高，并且p-VP水平的升高与MD的眩晕发作密切相关。实验研究表明，水通道蛋白-2和加压素2型受体的蛋白和mRNA在耳蜗的血管纹和内淋巴囊的上皮中表达，并且内耳中的VP-AQP 2系统的活性介导了内淋巴室的体积。
Conclusions: Endolymph homeostasis is thought to be mediated by the vasopressin-aquaporin-2 (VP-AQP2) system in the inner ear. Endolymphatic hydrops, the morphological characteristics of Ménière’s disease (MD), seems to reflect the malregulation of the VP-AQP2 system in inner ear fluid. The elevation of plasma vasopressin (p-VP) level, which is often observed in MD and its related diseases, might be one of the causative factors underlying these diseases. Purpose of Review: Review of the role of the VP-AQP2 system in the inner ear fluid homeostasis and in the formation and development of endolymphatic hydrops. Recent Clinical and Experimental Findings: A clinical survey has revealed that the p-VP level is often elevated in MD and its related diseases and that the increase in the p-VP level was closely linked to vertigo attacks in MD. Experimental studies have revealed that proteins and mRNAs of aquaporin-2 and vasopressin type 2 receptor were expressed in the stria vascularis of the cochlea and the epithelium of the endolymphatic sac, and that the volume of the endolymphatic compartment was mediated by the activity of the VP-AQP2 system in the inner ear.