REV1 genetic variants associated with the risk of cervical carcinoma
REV1 genetic variants associated with the risk of cervical carcinoma
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DOI：
10.1007/s10654-008-9251-5
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发表时间：
2008-06-01
影响因子：
13.6
通讯作者：
Chen, Huaizeng
中科院分区：
文献类型：
--
作者：
He, Xiaohong;Ye, Feng;Chen, Huaizeng
目的探讨REV1基因变异对宫颈癌风险的影响。方法选取543例患者，其中癌282例，CIN 261例，正常对照480例。通过PCR测序对两个单核苷酸多态性（SNP）（REV1 Phe257Ser和REV1 Asn373Ser）进行基因分型，并分析其与包括HPV感染在内的临床特征的相关性。结果与REV1 Phe257Ser相比，携带Ser257Ser和Phe257Ser基因型的女性患宫颈癌或宫颈鳞癌的风险显着降低。相反，纯合 Ser373Ser 会增加患癌症的风险。此外，我们发现 Phe257Ser 和 Asn373Ser 与宫颈癌风险的关联是鳞状细胞癌特有的，与腺癌无关。我们的研究结果表明，携带 Phe257Ser 变异基因型的女性可降低患宫颈癌的风险，尤其是具有高危性生殖史的女性，而携带 Asn373Ser 变异基因型且具有高危性和生殖史的女性患宫颈癌的风险显着升高。结论 我们的结果支持 Phe257Ser 和 Ser257Ser 基因型与宫颈癌风险降低相关，而 Asn373Ser 和 Ser373Ser 基因型则增加风险。此外，在具有高风险性和生殖史的群体中，这种影响更为显着。
Purpose To explore the REV1 genetic variants effect the risk of cervical carcinoma. Methods Total 543 cases, including 282 carcinoma and 261 CIN, and 480 normal controls were performed. Two single nucleotide polymorphisms (SNPs) (REV1 Phe257Ser and REV1 Asn373Ser) were genotyped by PCR-squencing, and analysis the correlation to clinical character including HPV infection. Results Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma. On contrary, homozygous Ser373Ser increased the risk for carcinoma. In addition, we found that the association of Phe257Ser and Asn373Ser with the risk for cervical carcinoma was specific to squamous cell carcinomas and not relevant for adenocarcinoma. Our results suggest that women carry Phe257Ser variant genotype decrease the risk for cervical carcinoma, more in women that have high-risk sexual reproductive histories, when women who carried Asn373Ser variant genotype and had high-risk sexual and reproductive histories had a significantly elevated risk for cervical carcinoma. Conclusion Our results support Phe257Ser and Ser257Ser genotypes are associated with a decreased risk for cervical carcinoma, while Asn373Ser and Ser373Ser genotypes increased the risk. In addition, the effects were more significant in the groups with high-risk sexual and reproductive histories.