COGNITIVE DYSFUNCTION IN MULTIPLE-SCLEROSIS .2. IMPACT ON EMPLOYMENT AND SOCIAL FUNCTIONING
COGNITIVE DYSFUNCTION IN MULTIPLE-SCLEROSIS .2. IMPACT ON EMPLOYMENT AND SOCIAL FUNCTIONING
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DOI：
10.1212/wnl.41.5.692
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发表时间：
1991-05-01
期刊：
影响因子：
9.9
通讯作者：
UNVERZAGT, F
中科院分区：
文献类型：
--
作者：
RAO, SM;LEO, GJ;UNVERZAGT, F
我们设计了一项研究来评估认知功能障碍对多发性硬化症患者日常生活问题的具体贡献。 根据综合神经心理测试的结果，我们将100例MS患者分为认知完整（N = 52）或认知受损（N = 48）。 除了神经系统检查外，MS患者还完成了关于情绪和社会功能的问卷调查，进行了全面的家庭职业治疗评估，并由近亲或朋友对特定的人格特征进行了评价。 虽然两组在身体残疾和疾病持续时间方面没有显著差异，但认知受损组的患者不太可能工作，参与较少的社交和运动活动，报告更多的性功能障碍，在执行日常家务方面遇到更大的困难，并且比认知完好的患者表现出更多的精神病理学。 这些发现表明，认知功能障碍是决定MS患者生活质量的主要因素。
We designed a study to assess the specific contribution of cognitive dysfunction to multiple sclerosis patients' problems in daily living. Based on the results of a comprehensive neuropsychological test battery, we classified 100 MS patients as either cognitively intact (N = 52) or cognitively impaired (N = 48). In addition to a neurologic examination, MS patients completed questionnaires on mood and social functioning, underwent a comprehensive in-home occupational therapy evaluation, and were rated by a close relative or friend regarding specific personality characteristics. While there were no significant differences between the two groups on measures of physical disability and illness duration, patients in the cognitively impaired group were less likely to be working, engaged in fewer social and avocational activities, reported more sexual dysfunction, experienced greater difficulty in performing routine household tasks, and exhibited more psychopathology than cognitively intact patients. These findings suggest that cognitive dysfunction is a major factor in determining the quality of life of patients with MS.