Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
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DOI：
10.1007/s10856-008-3641-9
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发表时间：
2009-04-01
影响因子：
3.7
通讯作者：
Chang, Jiang
中科院分区：
文献类型：
--
作者：
Huan, Zhiguang;Chang, Jiang
将CaHPO 4中心点A2 H（2）O（DCPD）和Ca 3SiO 5（C3 S）与0.75M磷酸钠缓冲液（pH = 7.0）混合，制备了一种新型低温固化磷酸-硅酸钙水泥。研究了液粉比（L/P）为0.6ml/g的DCPD/C3 S浆体的凝结时间、可注性、降解性和抗压强度等自凝性能，并与DCPD/CaO水泥体系进行了比较。结果表明，当C3 S质量分数为20%~ 40%时，DCPD/C3 S水泥浆体可在20 min内凝结，水化水泥的抗压强度（24 h后约为34.0 MPa）显著高于DCPD/CaO水泥体系（约10.0 MPa）。通过体外模拟体液（SBF）浸泡12 h考察了骨水泥的pH值，结果表明DCPD/C3 S对SBF的pH值无明显升高或降低作用。此外，复合骨水泥比DCPD/CaO骨水泥具有更好的支持和刺激细胞增殖的能力。新型DCPD/C3 S骨水泥具有良好的水硬性、良好的生物相容性和适度的可降解性，有望成为一种潜在的骨替代材料。
In this study, a novel low temperature setting calcium phosphate-silicate cement was obtained by mixing CaHPO4 center dot A 2H(2)O (DCPD) and Ca3SiO5 (C3S) with 0.75 M sodium phosphate buffers (pH = 7.0) as liquid phase. The self-setting properties of the obtained DCPD/C3S paste with liquid to powder ratio (L/P) of 0.6 ml/g, such as setting times, injectability, degradability and compressive strength were investigated and compared with that of DCPD/CaO cement system. The results indicated that, with the weight ratio of C3S varied from 20% to 40%, the workable DCPD/C3S pastes could set within 20 min, and the hydrated cement showed significantly higher compressive strength (around 34.0 MPa after 24 h) than that of the DCPD/CaO cement system (approximately 10.0 MPa). Furthermore, the in vitro pH value of the cements was investigated by soaking in simulated body fluid (SBF) for 12 h, and the result indicated that the DCPD/C3S did not induce significant increase or decrease of pH value in SBF. Additionally, the composite cement possesses better ability to support and stimulate cell proliferation than the DCPD/CaO cement. With good hydraulic properties, improved biocompatibility and moderate degradability, the novel DCPD/C3S bone cement may be a potential candidate as bone substitute.