THE PSYCHOLOGICAL AND PHYSIOLOGICAL-EFFECTS OF MDMA ON NORMAL VOLUNTEERS
THE PSYCHOLOGICAL AND PHYSIOLOGICAL-EFFECTS OF MDMA ON NORMAL VOLUNTEERS
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DOI：
10.1080/02791072.1986.10472366
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发表时间：
1986-10-01
影响因子：
2.8
通讯作者：
DOWNING, J
中科院分区：
文献类型：
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作者：
DOWNING, J
材料与方法21名健康志愿者单次暴露于M））1\1A进行了初步研究，以提供心血管基线数据。生化和呼吸道参数。通过将志愿受试者限制为至少服用过一次MDMA的人，从而满足了该实验材料对usc的知情同意。除了由于缺乏第一次不安或排除了可能倾向于焦虑经历的受试者而可能减少焦虑产生的心理生理反应外，无法容易地估计这种先前的经验因素引入的偏倚。因为只有具有以前良好经验的人才会自愿。所有21名受试者都是研究人员的一名成员。他们说他们身体健康（有两个例外），被认为精神稳定。无论是自己的账户还是员工的账户。两名健康状况异常的人都有眼部问题。一个患有青光眼，另一个因视网膜变性而失明。
MATERIALS AND METHODSA pilot study of the effects of a single exposure to M)) 1\1A in 21 healthy volunteers was conducted to provide baseline data on cardiovascular. biochemical and ncurobchavioral parameters. Informed conse nt for the usc of this experimental material was met by limiting the volunteer subjects to persons who had already taken MDMA at least once and thus had a basis for anti cipating their experiences. Wh at bias was introduced by this pre vious experience factor cannot be readily estimated-other than a possible reduction in anxiety-produced psychophysiological responses due to absence of firsttime uneasiness or the exclusion of subjects potentially prone to negati ve experiences. inasmuch as onl y persons with previously favorable experiences would volunteer. All 21 subjects were personally known to a member of the research staff. stated they were in good health (with two exceptions) and were considered mentally stable. both by their own account and by the staff. The two health exceptions were both individuals with ocular problems. one with glaucoma and the other being legally blind from retinal degeneration.