Organization of corticostriatal projections from the vibrissal representations in the primary motor and somatosensory cortical areas of rodents
Organization of corticostriatal projections from the vibrissal representations in the primary motor and somatosensory cortical areas of rodents
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DOI：
10.1002/cne.1337
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发表时间：
2001-10-08
影响因子：
2.5
通讯作者：
Alloway, KD
中科院分区：
文献类型：
--
作者：
Hoffer, ZS;Alloway, KD
为了表征啮齿动物感觉运动皮层的皮质纹状体投射，将顺行示踪剂生物素化葡聚糖胺（BDA）和荧光红（FR）注射到初级运动（MI）和体感（SI）皮层的触须代表中。重建标记的终端和他们的珠状静脉曲张在新纹状体和丘脑进行了定量分析，以确定在这两个皮质下结构的标记重叠的程度。皮质纹状体预测从触须代表MI更广泛的比相应的预测从SI。这两个皮质区发送密集的预测，背外侧新纹状体，但MI触须代表也预计位于更喙和内侧的地区。尽管有这些差异，MI和SI都投射到背外侧新纹状体的重叠部分。在两个皮质区的示踪剂注射也产生了密集的顺行和逆行标记在内侧部门的后复杂的丘脑（POM）。因为POm是体细胞组织的，并且具有相互作用。在与SI和MI皮质两者的连接中，POm中标记的重叠的量用于指示示踪剂是否被注射到MI和SI的相应晶须表示中。我们发现，标记的重叠在新纹状体的比例是高度相关的标记的重叠在POM的量。这些结果表明，啮齿类动物的新纹状体接收会聚投射从相应的区域在MI和SI皮层。此外，丘脑皮质投射的POm表明，它可以调制皮质纹状体输出相应的代表在MI和SI。(C)2001 Wiley-Liss，Inc.
To characterize corticostriatal projections from rodent sensorimotor cortex, the anterograde tracers biotinylated dextran amine (BDA) and fluororuby (FR) were injected into the whisker representations of the primary motor (MI) and somatosensory (SI) cortices. Reconstructions of labeled terminals and their beaded varicosities in the neostriatum and thalamus were analyzed quantitatively to determine the degree of labeled overlap in both of these subcortical structures. Corticostriatal projections from the vibrissal representation in MI were more extensive than corresponding projections from SI. Both cortical areas sent dense projections to the dorsolateral neostriatum, but the MI vibrissal representation also projected to regions located more rostrally and medially. Despite these differences, both MI and Sl projected to overlapping parts of the dorsolateral neostriatum. Tracer injections in both cortical areas also produced dense anterograde and retrograde labeling in the medial sector of the posterior complex of the thalamus (POm). Because POm is somatotopically organized and has reciprocal. connections with both Sl and MI cortices, the amount of labeled overlap in POm was used to indicate whether the tracers were injected into corresponding whisker representations of MI and SI. We found that the proportion of labeled overlap in the neostriatum was highly correlated with the amount of labeled overlap in POm. These results indicate that the rodent neostriatum receives convergent projections from corresponding regions in MI and SI cortex. Furthermore, the thalamocortical projections of the POm indicate that it may modulate corticostriatal outputs from corresponding representations in MI and SI. (C) 2001 Wiley-Liss, Inc.