Carcinogenic and cocarcinogenic effects of radon and radon daughters in rats.
Carcinogenic and cocarcinogenic effects of radon and radon daughters in rats.
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DOI：
10.1289/ehp.9410264
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发表时间：
1994-01
影响因子：
10.4
通讯作者：
Masse R
中科院分区：
文献类型：
--
作者：
Monchaux G;Morlier JP;Morin M;Chameaud J;Lafuma J;Masse R
以前已经确定，大鼠暴露于氡和氡子体中可诱发肺癌。虽然在大鼠中未发现人类常见的燕麦细胞癌，但其他组织学类型的肺癌，特别是鳞状细胞癌和原始肺腺癌，与在人类中观察到的相似。累积剂量从25至3000工作水平月（WLM），这是类似的中等和高累积剂量在铀矿工人中观察到的剂量效应关系。该实验方案也被用来研究其他环境或工业空气污染物，如烟草烟雾，矿物纤维，柴油机废气，或金属矿矿石，可能与氡暴露协同作用的矿物的潜在cocarcinogenic影响。在暴露于氡和烟草烟雾组合的大鼠中，肺癌的发病率根据累积氡暴露和烟草烟雾暴露的持续时间高出2-4倍。当胸膜内注射矿物纤维时，在暴露于氡和纤维组合的大鼠中观察到恶性胸部肿瘤的发病率增加，但协同效应导致相加。与只暴露于氡的大鼠相比，柴油机废气或来自金属矿石的矿物质，观察到肺癌的发病率略有增加，但不显著。这些结果表明，它是可能的，以建立潜在的致癌作用，表现出倍增，添加剂，或没有效果的各种环境或工业空气中的污染物与氡暴露相结合。该氡模型可用于研究两种职业暴露之间可能的相互作用。
It has been previously established that lung cancer could be induced in rats by exposure to radon and radon daughters. Although the oat-cell carcinomas that are common in humans were not found in rats, other histological types of lung carcinomas, especially squamous cell carcinomas and primitive lung adenocarcinomas, were similar to those observed in humans. A dose-effect relationship was established for cumulative doses varying from 25 to 3000 working-level-months (WLM), which was similar for medium and high cumulative doses to that observed in uranium miners. This experimental protocol was also used to study the potential cocarcinogenic effects of other environmental or industrial airborne pollutants such as tobacco smoke, mineral fibers, diesel exhausts, or minerals from metallic mine ores that may act synergistically with radon exposure. In rats exposed to radon and tobacco smoke combined, the incidence of lung cancers was higher by a factor of 2-4 according to the cumulative radon exposure and the duration of tobacco smoke exposure. When mineral fibers were injected intrapleurally, an increased incidence of malignant thoracic tumors was observed in rats exposed to radon and fibers combined, but synergistic effects resulted in additivity. With diesel exhausts or minerals from metallic ores, a slight, nonsignificant increase in the incidence of lung carcinomas was observed compared with rats exposed to radon alone. These results demonstrated that it is possible to establish the potential cocarcinogenic action, showing either multiplicative, additive, or no effect of various environmental or industrial airborne pollutants combined with radon exposure. This radon model is valid for investigating possible interactions between two occupational exposures.