TISSUE DISTRIBUTION AND MAGNETIC-RESONANCE SPIN-LATTICE RELAXATION EFFECTS OF GADOLINIUM-DTPA
TISSUE DISTRIBUTION AND MAGNETIC-RESONANCE SPIN-LATTICE RELAXATION EFFECTS OF GADOLINIUM-DTPA
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DOI：
10.1148/radiology.154.3.3969477
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发表时间：
1985-01-01
期刊：
影响因子：
19.7
通讯作者：
SLUTSKY, RA
中科院分区：
文献类型：
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作者：
STRICH, G;HAGAN, PL;SLUTSKY, RA
钆-DTPA [二亚乙基三胺五乙酸]复合物（Gd-DTPA）是一种潜在的临床磁共振（MR）造影剂，主要通过降低其定位组织中的自旋-晶格弛豫时间（T1）来增强图像。本研究旨在确定静脉注射Gd-DTPA在选定的感兴趣器官中的即时组织分布，作为给药剂量和组织Gd-DTPA浓度的函数。以以下剂量对3组家兔静脉注射Gd-DTPA和示踪量的Gd-153：0.01 mM/kg（n = 6）; 0.05 mM/kg（n = 6）; 010 mM/kg（n = 6）。对照组接受假注射。Gd-DTPA给药后5分钟，处死所有动物;在0.25 T MR光谱仪中分析血清、肺、心脏、肾脏、肝脏和脾脏的样品以测量T1，然后测量γ。孔计数器测定组织中Gd-DTPA的浓度。注射后5分钟的组织分布（%剂量/组织重量，g）在给定剂量范围内成比例恒定。组织浓度随注射剂量线性变化（所有组织的r > 0.98）。弛豫率（1/T1）与注射剂量和组织Gd-DTPA浓度呈线性关系（r > 0.97）。对给定剂量的组织松弛率反应顺序为肾脏>血清>肺>心脏>肝脏>脾脏。由于其细胞外分布和线性弛豫率与浓度的关系，Gd-DPTA在MR图像中的增强可能是相对器官灌注的良好标记。
Gadolinium-DTPA [diethylenetriaminepentaacetic acid] complex (Gd-DTPA) is a potential clinical magnetic resonance (MR) contrast agent that enhances images primarily by decreasing spin-lattice relaxation time (T1) in tissues in which it localizes. This study was designed to determine the immediate tissue distribution of i.v. administered Gd-DTPA in selected organs of interest as a function of administered dose and tissue Gd-DTPA concentration. An i.v. bolus of Gd-DTPA with a tracer quantity of Gd-153 was administered to 3 groups of rabbits at the following doses: 0.01 mM/kg (n = 6); 0.05 mM/kg (n = 6); 010 mM/kg (n = 6). A control group received sham injections. Five min after Gd-DTPA was administered, all animals were killed; samples of serum, lung, heart, kidney, liver and spleen were analyzed in a 0.25 T MR spectrometer to measure T1, and then in a .gamma. well counter to determine tissue concentration of Gd-DTPA. Tissue distribution (% dose/tissue wt in g) at 5 min after injection was proportionally constant over the range of doses given. Tissue concentration varied linearly with injected dose (r > 0.98 for all tissues). Relaxation rate (1/T1) varied linearly with injected dose and with tissue Gd-DTPA concentration (r > 0.97 for all tissues). The order of tissue relaxation rate response to a given dose was kidney > serum > lung > heart > liver > spleen. Because of its extracellular distribution and linear relaxation rate vs. concentration relationship, Gd-DPTA enhancement in MR images may be a good marker of relative organ perfusion.