Anti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients
Anti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients
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DOI：
10.1371/journal.pone.0151911
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发表时间：
2016-03-17
期刊：
影响因子：
3.7
通讯作者：
Blom, Dirk
中科院分区：
文献类型：
--
作者：
Dave, Joel A.;Levitt, Naomi S.;Blom, Dirk
研究目的撒哈拉以南非洲HIV感染者血脂异常患病率及相关危险因素的数据很少。我们进行了横断面分析，在一个队列中的HIV感染的南非adultes.MethodsWe研究HIV感染的患者是抗逆转录病毒治疗（ART）-幼稚或接受非核苷类逆转录酶抑制剂（NNRTI）为基础的或蛋白酶抑制剂（PI）为基础的ART. Evaluation包括空腹脂图，口服葡萄糖耐量试验和临床人体测量。血脂异常的定义使用NCEP ATP III guidelines.ResultsThe中位年龄的参与者是34岁（范围19-68岁）和78%的女性。406名ART初治者和551名ART参与者的血脂异常患病率分别为90.0%和85%。低HDL胆固醇（HDLC）是最常见的异常[290/406（71%）ART初治受试者和237/551（43%）ART受试者]。接受ART的参与者的甘油三酯（TG）、总胆固醇（TC）、LDL-胆固醇（LDLC）和HDL-胆固醇高于ART初治组。严重血脂异常（LDLC > 4.9 mmol/L或TG > 5.0 mmol/L），
PurposeData on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a cohort of HIV-infected South African adults.MethodsWe studied HIV-infected patients who were either antiretroviral therapy (ART)-naive or receiving non-nucleoside reverse transcriptase inhibitor (NNRTI)-based or protease inhibitor (PI)-based ART. Evaluation included fasting lipograms, oral glucose tolerance tests and clinical anthropometry. Dyslipidemia was defined using the NCEP ATPIII guidelines.ResultsThe median age of the participants was 34 years (range 19-68 years) and 78% were women. The prevalence of dyslipidemia in 406 ART-naive and 551 participants on ART was 90.0% and 85%, respectively. Low HDL-cholesterol (HDLC) was the most common abnormality [290/406 (71%) ART-naive and 237/551 (43%) ART-participants]. Participants on ART had higher triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLC) and HDLC than the ART-naive group. Severe dyslipidaemia, (LDLC > 4.9 mmol/L or TG > 5.0 mmol/L) was present in