SYNDROME OF MULTIPLE CONGENITAL ANOMALIES ASSOCIATED WITH TERATOGENIC EXPOSURE
SYNDROME OF MULTIPLE CONGENITAL ANOMALIES ASSOCIATED WITH TERATOGENIC EXPOSURE
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DOI：
10.1080/00039896.1975.10666626
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
NORA, JJ
中科院分区：
文献类型：
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作者：
NORA, AH;NORA, JJ
一项对19名患有多处先天性异常（首字母缩写为VEGEL）（脊椎、肛门、心脏、气管食管、肾脏和肢体）的患者进行的研究显示，13名患者在胚胎发育的脆弱期暴露于孕激素/雌激素化合物或仅暴露于孕激素。这些激素被用作“妊娠试验”，以及其他各种各样的原因。VEGFRIL患者与配对和匹配的对照组的比较，一组染色体异常（除了唐氏综合征）和另一组功能性杂音，揭示了一个显着的差异，就暴露于激素避孕药。和胃肠道结构概括了沙利度胺综合征中涉及的系统，但呈现出模式的变化。在获得更确切的数据之前，谨慎的做法是强调在开始口服避孕药之前需要核实没有怀孕，并停止使用激素药物作为怀孕试验。
A study of 19 patients with multiple congenital anomalies described by the acronym VACTERL (Vertebral, Anal, Cardiac, Tracheoesophageal, Renal, and Limb) revealed exposure at the vulnerable period of embryogenesis to a progestogen/estrogen compound or a progestogen alone in 13 patients. These hormones were taken as a “pregnancy test,” and for a variety of other reasons.Comparison of VACTERL patients with paired and matched controls, one group with chromosomal anomalies (other than Down syndrome) and another group with functional murmurs, revealed a significant difference with respect to exposure to hormonal contraceptives.The multiple anomalies of skeletal, cardiovascular, and gastrointestinal structures recapitulate the systems involved in the thalidomide syndrome, but present a variation of the pattern. Until more definitive data are available it would be prudent to emphasize the need to verify the absence of pregnancy before initiation of oral contraception and to discontinue hormonal agents as tests for pregnancy.