How cells get the right chromosomes
How cells get the right chromosomes
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DOI：
10.1126/science.275.5300.632
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发表时间：
1997-01-31
期刊：
影响因子：
56.9
通讯作者：
Nicklas, RB
中科院分区：
文献类型：
--
作者：
Nicklas, RB
当细胞分裂时，染色体必须被无条件地传递到子细胞。缺失或额外的染色体会导致出生缺陷和癌症。偶然事件是染色体传递的起点，这使得该过程容易出错，通过多种使用来自有丝分裂力的机械张力来避免错误。张力稳定正确的染色体构型，控制细胞周期检查点，并改变染色体化学。
When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error, Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.