A variant TATA box in the bilirubin UDP-glucuronosyltransferase 1 gene promoter does not contribute to neonatal jaundice in the Japanese population
A variant TATA box in the bilirubin UDP-glucuronosyltransferase 1 gene promoter does not contribute to neonatal jaundice in the Japanese population
复制标题
胆红素 UDP-葡萄糖醛酸基转移酶 1 基因启动子中的 TATA 盒变异不会导致日本新生儿黄疸
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
K. Sumino
中科院分区：
文献类型：
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作者：
S. Waku;Y. Takeshima;H. Nakamura;H. Nishio;K. Sumino
编辑器-A变体TATA盒据报道，胆红素UDP-葡萄糖醛酸基转移酶1（BUGT 1）基因启动子区的A[TA] 7 TAA（命名为TA-7）可加速出生后前两天胆红素浓度的升高。1然而，TA-7与新生儿期胆红素峰值浓度之间的关系尚未阐明，TA-7是否影响不同种族婴儿的胆红素代谢也不清楚。
为了研究TA-7是否是日本人群中新生儿黄疸的危险因素之一，我们对74名日本新生儿进行了BUGT 1基因的基因分型分析，并测量了健康婴儿（n=55）4-5日龄时的胆红素浓度和需要治疗、光疗或换血的黄疸婴儿（n=19）的峰值胆红素浓度。…
Editor—A variant TATA box (A[TA]7TAA, designated as TA-7) in the promoter region of the bilirubin UDP-glucuronosyltransferase 1 (BUGT1) gene has been reported to accelerate the increase in bilirubin concentration during the first two days of life.1 However, the relation between TA-7 and peak bilirubin concentration in the neonatal period has not been clarified, and it is also unclear as to whether TA-7 influences bilirubin metabolism in infants of different ethnic groups.
To investigate whether TA-7 is one of the risk factors for neonatal jaundice in the Japanese population, we performed genotyping analysis of the BUGT1 gene in 74 Japanese newborn infants, and measured bilirubin concentrations at 4–5 days of age in healthy infants (n=55) and peak bilirubin concentrations in infants with jaundice requiring treatment, phototherapy, or exchange transfusion (n=19). …
影响因子：
5.1
作者：
Bancroft, JD;Kreamer, B;Gourley, GR
通讯作者：
Gourley, GR