Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.
Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.
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DOI：
10.2337/dc09-1754
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发表时间：
2010-05
期刊：
影响因子：
16.2
通讯作者：
Hammarlund C
中科院分区：
文献类型：
--
作者：
Löndahl M;Katzman P;Nilsson A;Hammarlund C
慢性糖尿病足溃疡是患者和卫生保健系统的主要关注点。本研究的目的是评估高压氧治疗（HBOT）在慢性糖尿病足溃疡管理中的作用。高压氧治疗糖尿病慢性足溃疡（HODFU）研究是一项随机、单中心、双盲、安慰剂对照的临床试验。接受HBOT治疗组的结果与接受高压空气治疗组的结果进行了比较。治疗在一个多位置的高压舱中进行，每天85分钟（疗程持续时间95分钟），每周5天，持续8周（40次治疗）。本研究在门诊环境中进行。研究了94例瓦格纳2、3或4级溃疡患者，这些患者存在时间>3个月。在意向治疗分析中，37例患者在1年随访时实现了索引溃疡的完全愈合：HBOT组25/48（52%），安慰剂组12/42（29%）（P = 0.03）。在对完成>35次HBOT治疗的患者进行的亚组分析中，HBOT组23/38（61%）和安慰剂组10/37（27%）的索引溃疡愈合（P = 0.009）。不良事件发生率低。HODFU研究表明，HBOT的连续治疗有助于选定糖尿病患者慢性足部溃疡的愈合。
Chronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers. The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study was a randomized, single-center, double-blinded, placebo-controlled clinical trial. The outcomes for the group receiving HBOT were compared with those of the group receiving treatment with hyperbaric air. Treatments were given in a multi-place hyperbaric chamber for 85-min daily (session duration 95 min), five days a week for eight weeks (40 treatment sessions). The study was performed in an ambulatory setting. Ninety-four patients with Wagner grade 2, 3, or 4 ulcers, which had been present for >3 months, were studied. In the intention-to-treat analysis, complete healing of the index ulcer was achieved in 37 patients at 1-year of follow-up: 25/48 (52%) in the HBOT group and 12/42 (29%) in the placebo group (P = 0.03). In a sub-analysis of those patients completing >35 HBOT sessions, healing of the index ulcer occurred in 23/38 (61%) in the HBOT group and 10/37 (27%) in the placebo group (P = 0.009). The frequency of adverse events was low. The HODFU study showed that adjunctive treatment with HBOT facilitates healing of chronic foot ulcers in selected patients with diabetes.
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影响因子：
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