Evidence for Specific Genotype-Dependent Immune Priming in the Lophotrochozoan Biomphalaria glabrata Snail
Evidence for Specific Genotype-Dependent Immune Priming in the Lophotrochozoan Biomphalaria glabrata Snail
复制标题
DOI：
10.1159/000345909
复制
发表时间：
2013-01-01
影响因子：
5.3
通讯作者：
Gourbal, Benjamin
中科院分区：
文献类型：
--
作者：
Portela, Julien;Duval, David;Gourbal, Benjamin
历史上，无脊椎动物免疫领域的主流观点是，不具有获得性适应性免疫的无脊椎动物依赖于具有低特异性和无记忆的先天机制。最近的几项研究动摇了这种范式，并表明无脊椎动物的免疫防御比以前认为的更复杂和特异。越来越多的证据表明，至少有一些无脊椎动物（主要是蜕皮动物）在对不同病原体的免疫反应中表现出高度的特异性，随后的再接触可能会导致增强的保护（最近称为“免疫引发”）。在这里，我们调查了免疫启动Lophotrochozoan蜗牛种Biomphalaria光滑，感染吸虫病原体曼氏血吸虫。我们证实，无论宿主菌株是什么，蜗牛都能免受继发性同源感染。然后，我们研究了免疫启动如何发生和B的特异性水平。光滑果免疫启动。在这份报告中，我们证实了免疫启动的存在，我们确定了一个基因型依赖的免疫启动的淡水蜗牛B。光滑的版权所有（C）2013 S. Karger AG，巴塞尔
Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more complex and specific than previously thought. Mounting evidence has shown that at least some invertebrates (mainly Ecdysozoa) show high levels of specificity in their immune responses to different pathogens, and that subsequent reexposure may result in enhanced protection (recently called 'immune priming'). Here, we investigated immune priming in the Lophotrochozoan snail species Biomphalaria glabrata, following infection by the trematode pathogen Schistosoma mansoni. We confirmed that snails were protected against a secondary homologous infection whatever the host strain. We then investigated how immune priming occurs and the level of specificity of B. glabrata immune priming. In this report we confirmed that immune priming exists and we identified a genotype-dependent immune priming in the fresh-water snail B. glabrata. copyright (C) 2013 S. Karger AG, Basel