Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer
Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer
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DOI：
10.1007/s11748-010-0603-1
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发表时间：
2010-08-01
影响因子：
1.2
通讯作者：
Sakuma, Tsutomu
中科院分区：
文献类型：
--
作者：
Usuda, Katsuo;Sagawa, Motoyasu;Sakuma, Tsutomu
目的。本研究的目的是在正电子发射断层扫描(PET)上确定肺癌组织中葡萄糖转运蛋白-1(Glut1)的表达与F-18-FDG(F-18-氟-2-脱氧葡萄糖)摄取的相关性，并比较两者的异同。本研究对34例手术切除的原发性肺癌患者进行了研究。腺癌17例，鳞癌12例，其他细胞癌5例。免疫组化Glut1强度分为三组：阴性组、阳性组和强阳性组。Glut1频率由阳性细胞在所有癌细胞中的比例定义，并以10%的增量在0-100%的半定量范围内分级。数据以平均值+/-SD表示。最大标准摄取值(SUVmax)在“阴性”Glut1强度组为4.8+/-6.3，“阳性”Glut1强度组为4.7+/-3.1，“强阳性”Glut1组为11.2+/-5.2。虽然SUVmax与肿瘤大小显著相关(相关系数0.58，P=0.00033)，但Glut1频率与肿瘤大小无显著相关性(相关系数0.18，P=0.301)。细胞类型和细胞分化程度与Glut1表达和F-18-FDG摄取显著相关。Glut1的表达与F-18-FDG摄取显著相关。Glut1表达和F-18-FDG摄取在细胞分化和细胞类型上有相似之处。F-18-FDG摄取与肿瘤大小显著相关，但Glut1表达与肿瘤大小无关。
Purpose. The aim of this study was to determine if glucose transporter-1 (Glut1) expression correlates with F-18-FDG (F-18-fluoro-2-deoxyglucose) uptake on positron emission tomography (PET) in lung cancer and to examine the similarities and differences between them.Methods. A total of 34 patients with resected primary lung cancers were investigated in this study. There were 17 adenocarcinomas, 12 squamous cell carcinomas, and 5 cancers of other cell types. Immunohistochemical Glut1 intensity was categorized into three groups: negative, positive, and strongly positive. Glut1 frequency was defined by the proportion of positive cells among all cancer cells, and it was graded on a semiquantitative scale as 0-100% in 10% increments. The data are expressed as the mean +/- SD.Results. Maximum standardized uptake values (SUVmax) were 4.8 +/- 6.3 in "negative" Glut1 intensity cases, 4.7 +/- 3.1 in "positive" Glut1 intensity cases, and 11.2 +/- 5.2 in "strongly positive" Glut1 intensity cases. Although SUVmax correlated significantly with tumor size (correlation coefficient 0.58, P = 0.00033), Glut1 frequency did not correlate significantly with tumor size (correlation coefficient 0.18, P = 0.301). Cell type and cell differentiation correlated significantly with Glut1 expression and F-18-FDG uptake.Conclusion. Glut1 expression correlates significantly with F-18-FDG uptake. There are similarities in cell differentiation and cell type between Glut1 expression and F-18-FDG uptake. F-18-FDG uptake correlates significantly with tumor size, but Glut1 expression does not.