Rhodium-Catalyzed Intermolecular Amidation of Arenes with Sulfonyl Azides via Chelation-Assisted C-H Bond Activation
Rhodium-Catalyzed Intermolecular Amidation of Arenes with Sulfonyl Azides via Chelation-Assisted C-H Bond Activation
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DOI：
10.1021/ja303527m
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发表时间：
2012-06-06
影响因子：
15
通讯作者：
Chang, Sukbok
中科院分区：
文献类型：
--
作者：
Kim, Ji Young;Park, Sae Hume;Chang, Sukbok
我们报道了用磺酰叠氮作为氨基源直接酰胺化芳烃的C-H键，释放N-2作为单一副产物。该反应是在大气环境中无氧化剂条件下由阳离子铑络合物催化的。广泛的含螯合基团芳烃被选择性修饰，具有良好的官能团耐受性，从而为实际分子间C-N键的形成开辟了新的途径。
We report the direct amidation of arene C-H bonds using sulfonyl azides as the amino source to release N-2 as the single byproduct. The reaction is catalyzed by a cationic rhodium complex under external oxidant-free conditions in the atmospheric environment. A broad range of chelate group-containing arenes are selectively amidated with excellent functional group tolerance, thus opening a new avenue to practical intermolecular C-N bond formation.