Effect of cigarette smoking in epidemiological studies of lung cancer.
Effect of cigarette smoking in epidemiological studies of lung cancer.
复制标题
吸烟对肺癌流行病学研究的影响。
DOI：
10.1002/sim.4780070124
复制
发表时间：
1988
影响因子：
2
通讯作者：
Whittemore,AS
中科院分区：
文献类型：
--
作者：
Whittemore,AS
本文描述了一种调整职业/环境肺癌风险分析的方法，用于队列和病例对照研究中吸烟的影响。该方法使用一个函数，将个人的死亡率与他的年龄和吸烟史联系起来。两个这样的功能进行检查。第一个取决于吸烟的总包数和年龄。第二种基于致癌作用的多阶段理论，取决于年龄、开始吸烟的年龄和随后的吸烟率。将这两个函数预测的肺癌发病率与英国男性医生和美国退伍军人的队列研究以及新墨西哥州非西班牙裔白色男性的病例对照研究中观察到的结果进行比较。队列数据集均未区分这两个函数的拟合。新墨西哥州的数据与第二个函数拟合得更好，尽管这两个函数都高估了戒烟者的死亡率。每一个功能解释了更多的变化，在新墨西哥州的数据比任何几个逻辑回归模型，涉及分类变量的年龄和吸烟。
This paper describes a method for adjusting the analysis of occupational/environmental lung cancer risks for the effects of cigarette smoking in cohort and case‐control studies. The method uses a function that relates an individual's death rate to his age and cigarette smoking history. Two such functions are examined. The first depends on total packs of cigarettes smoked and age. The second, based on the multistage theory of carcinogenesis, depends on age, age at start of smoking, and subsequent smoking rates. The lung cancer rates predicted by these two functions are compared to those observed in cohort studies of male British physicians and U.S. veterans, and in a case‐control study of non‐Hispanic white men in New Mexico. Neither of the cohort data sets distinguished the fit of the two functions. The New Mexico data were fit better by the second function, though both functions overpredicted death rates among ex‐smokers. Each function explained substantially more variation in the New Mexico data than did any of several logistic regression models involving categorical variables for age and smoking.