Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
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DOI：
10.1002/cam4.1062
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发表时间：
2017-05-01
期刊：
影响因子：
4
通讯作者：
Lee, Donghoon
中科院分区：
文献类型：
--
作者：
Farr, Navid;Wang, Yak-Nam;Lee, Donghoon
胰腺癌的临床前模型为确定肿瘤的发生机制和治疗的可能性提供了一种替代手段，为肿瘤的医学治疗提供了巨大的潜在资源。为了评估不同的肿瘤模型，可量化磁共振成像(MRI)技术可以在识别有价值的体内肿瘤特征生物标志物方面发挥重要作用。我们用多参数磁共振成像技术描述了三种胰腺癌模型。采用弥散加权成像和磁化转移(MT-MRI)技术测量肿瘤间质密度。组织学测量显示出与肿瘤纤维化水平类似的趋势。结果表明，MRI测量可以作为一种有价值的工具来识别和评估肿瘤的特征。
The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion-weighted imaging and magnetization transfer (MT-MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics.