Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa
Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa
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DOI：
10.1111/j.1440-1746.2006.04721.x
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发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Ishihara, Kazuhiko
中科院分区：
文献类型：
--
作者：
Ichikawa, Takafumi;Ota, Hiroyoshi;Ishihara, Kazuhiko
背景和目的：拉呋替丁是一种新型组胺H-2受体拮抗剂，在日本主要用作抗分泌剂。以前的人类研究没有评估其胃保护作用。本研究的目的是确定拉呋替丁对人胃粘液层的影响，使用组织学和生物化学methods.Methods：安排胃切除术谁同意参加的14例患者中，7人给予14天的拉呋替丁20毫克/天（拉呋替丁组），其他人没有接受任何药物治疗（对照组）。对Carnoy固定的组织切片中的表面粘液凝胶层进行了免疫化学检查。结果：两组间胃炎分级及免疫组化染色特征均无显著性差异。拉呋替丁给药后，表面粘液凝胶层的层状结构得以保留，并且比对照组中的层厚。拉呋替丁组的表层粘蛋白是对照组的3倍。有两组之间的深层mucosa.Conclusion粘蛋白含量无差异：拉呋替丁，在临床剂量，不仅抑制胃酸分泌，但也加强了人胃粘膜的粘液屏障。
Background and Aim: Lafutidine is a novel histamine H-2-receptor antagonist used primarily as an antisecretory agent in Japan. Previous human studies have not assessed its gastroprotective effects. The purpose of the present study was to determine the effects of lafutidine on the human gastric mucus layer using both histological and biochemical methods.Methods: Of the 14 patients scheduled for gastrectomy who consented to participate, seven were given 14 days of lafutidine 20 mg/day (lafutidine group) and the others received no medication (control group). The surface mucus gel layer in Carnoy-fixed tissue sections was examined immunohistochemically. Both the thickness of the mucus layer and its mucin content were measured in gastric corpus mucosa.Results: There was no detectable difference between the groups in the grade of gastritis or the immunohistochemical staining characteristics. The laminated structure of the surface mucus gel layer was retained after administration of lafutidine and it was thicker than the layer in the control group. The surface layer in the lafutidine group had three-fold more mucin than that in the control group. There was no difference between the two groups in the mucin content of the deep mucosa.Conclusion: Lafutidine, given at clinical dosages, not only inhibits acid secretion but also strengthens the mucus barrier of the human gastric mucosa.