Metabolic and Molecular Imaging with Hyperpolarised Tracers
Metabolic and Molecular Imaging with Hyperpolarised Tracers
复制标题
使用超极化示踪剂进行代谢和分子成像
DOI：
--
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发表时间：
2018
影响因子：
3.1
通讯作者：
J. Hövener
中科院分区：
文献类型：
--
作者：
J. Skinner;L. Menichetti;A. Flori;A. Dost;Andreas B. Schmidt;M. Plaumann;F. Gallagher;J. Hövener
自进入临床以来，磁共振成像（MRI）已成为一种不可替代的放射学工具，因为它提供了人体内几乎所有器官和软组织的宏观信息，所有这些都不需要电离辐射。然而，MR的灵敏度太低，不能充分利用MR信号中包含的丰富的化学信息。超极化技术最近已经成为克服灵敏度限制的方法，通过与热平衡相比将MR信号增强许多数量级，从而实现一类新的基于代谢和分子X-核的MR示踪剂，其能够在细胞水平上报告代谢过程。这些超极化（HP）示踪剂有可能阐明许多器官和病理学的复杂代谢过程，迄今为止的研究主要集中在肿瘤学和心脏病学领域。本文综述了目前最有前景的超极化技术，如溶解动态核极化（d-DNP），仲氢诱导超极化（PHIP），蛮力超极化和自旋交换光泵（SEOP），然后讨论示踪剂检测方法，新兴的代谢示踪剂和应用以及在临床前和临床应用的进展。
Since reaching the clinic, magnetic resonance imaging (MRI) has become an irreplaceable radiological tool because of the macroscopic information it provides across almost all organs and soft tissues within the human body, all without the need for ionising radiation. The sensitivity of MR, however, is too low to take full advantage of the rich chemical information contained in the MR signal. Hyperpolarisation techniques have recently emerged as methods to overcome the sensitivity limitations by enhancing the MR signal by many orders of magnitude compared to the thermal equilibrium, enabling a new class of metabolic and molecular X-nuclei based MR tracers capable of reporting on metabolic processes at the cellular level. These hyperpolarised (HP) tracers have the potential to elucidate the complex metabolic processes of many organs and pathologies, with studies so far focusing on the fields of oncology and cardiology. This review presents an overview of hyperpolarisation techniques that appear most promising for clinical use today, such as dissolution dynamic nuclear polarisation (d-DNP), parahydrogen-induced hyperpolarisation (PHIP), Brute force hyperpolarisation and spin-exchange optical pumping (SEOP), before discussing methods for tracer detection, emerging metabolic tracers and applications and progress in preclinical and clinical application.
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DOI：
10.1039/c6cc00895j
发表时间：
2016-04-07
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Carroll VN;Truillet C;Shen B;Flavell RR;Shao X;Evans MJ;VanBrocklin HF;Scott PJ;Chin FT;Wilson DM
通讯作者：
Wilson DM
影响因子：
15
作者：
Chambers, Jennifer M.;Hill, P. Aru;Aaron, Julie A.;Han, Zhaohui;Christianson, David W.;Kuzma, Nicholas N.;Dmochowski, Ivan J.
通讯作者：
Dmochowski, Ivan J.
影响因子：
15
作者：
Colell JFP;Emondts M;Logan AWJ;Shen K;Bae J;Shchepin RV;Ortiz GX Jr;Spannring P;Wang Q;Malcolmson SJ;Chekmenev EY;Feiters MC;Rutjes FPJT;Blümich B;Theis T;Warren WS
通讯作者：
Warren WS
影响因子：
3.7
作者：
Kovtunov, Kirill V.;Kidd, Bryce E.;Koptyug, Igor V.
通讯作者：
Koptyug, Igor V.
影响因子：
4.9
作者：
Xiaoling Wang;Johannes E McKay;Bimala Lama;J. van Tol;Tinghui Li;Kyle Kirkpatrick;Zhehong Gan;Stephen Hill;Joanna R Long;Harry C. Dorn
通讯作者：
Xiaoling Wang;Johannes E McKay;Bimala Lama;J. van Tol;Tinghui Li;Kyle Kirkpatrick;Zhehong Gan;Stephen Hill;Joanna R Long;Harry C. Dorn