The hippocampal lamella hypothesis revisited
The hippocampal lamella hypothesis revisited
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DOI：
10.1016/s0006-8993(00)02991-7
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发表时间：
2000-12-15
期刊：
影响因子：
2.9
通讯作者：
Raastad, M
中科院分区：
文献类型：
--
作者：
Andersen, P;Soleng, AF;Raastad, M
我们已经重新检查了海马板层组织的CA3到CA1连接。基于一种新的技术与电生理量化的Schaffer侧支密度，并回顾最近的文献，我们得出结论，层状组织仍然是一个有用的概念，了解海马连接。使用片状海马体制备。包括整个CA1区，我们绘制了Schaffer侧支的分布通过两个程序。先在刺激CA3的一个点后，我们记录了CA1的各个部分的Schaffer复合动作电位的幅度。其次，我们绘制了CA1位置，我们可以逆向兴奋个别CA3神经元。尽管Schaffer侧枝从其起源的CA3细胞在一个宽的扇形区域内辐射。覆盖了CA1的大部分隔颞区。复合动作电位的幅度在横跨CA1朝向下托区的略微倾斜的横向带中最大。(C)2000 Elsevier Science B.V.保留所有权利。
We have re-examined the hippocampal lamellar organization of the CA3-to-CA1 connection. Based on a new technique with electrophysiological quantification of Schaffer collateral density, and a review of recent literature, we conclude that the lamellar organization remains a useful concept for understanding hippocampal connectivity. Using a sheet-like hippocampal preparation. containing the whole CA1 region, we mapped the distribution of Schaffer collaterals by two procedures. First. we recorded the amplitude of the Schaffer compound action potential in various parts of CA1 after stimulation of a point in CA3. Second, we charted the CA1 positions from which we could antidromically excite individual CA3 neurones. Although the Schaffer collaterals radiated from their CA3 cells of origin within a wide, fan-shaped area. covering a large part of the septo-temporal extent of CA1. the amplitude of the compound action potential was largest in a slightly oblique, transverse band across the CA1 towards the subicular region. (C) 2000 Elsevier Science B.V. All rights reserved.