Effect of tetracycline on the phagocytic function of human leukocytes.
Effect of tetracycline on the phagocytic function of human leukocytes.
复制标题
四环素对人白细胞吞噬功能的影响。
DOI：
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发表时间：
1974
影响因子：
6.4
通讯作者：
P. Quie
中科院分区：
文献类型：
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作者：
A. Forsgren;I. D. Schmeling;P. Quie
吞噬作用和细胞内杀死微生物是多形核中性白细胞的基本功能。抑菌抗生素只有在中性粒细胞功能正常的情况下才有效。因此，抑菌抗生素对白细胞功能的抑制可能具有重要的治疗意义。外周血白细胞的这些功能在抗菌治疗期间可能受到影响的可能性尚未得到广泛研究。本研究的目的是扩展早期研究四环素对人中性粒细胞吞噬细菌和酵母菌的影响。关于四环素对白细胞功能影响的报道一直存在矛盾。1950年，将抑制吞噬作用归因于氯四环素[1]。然而，在其他研究者后来的报告中，盐酸四环素没有表现出这种作用[2]。在最近的报告中，盐酸四环素已被证明可抑制人白细胞的趋化性[3，4]和氮蓝四唑染料（NBT）的最大还原[5]。在一项研究中，四环素类显示出抑制血清的杀菌作用，但不抑制细菌的调理作用[6]。
Phagocytosis and the intracellular killing of microbes are fundamental functions of polymorphonuclear neutrophil leukocytes. Bacteriostatic antibiotics are effective only with proper neutrophil function. Thus, inhibition of leukocyte function by bacteriostatic antibiotics may have important therapeutic implications. The possibility that these functions of peripheral blood leukocytes may be effected during antimicrobial therapy has not been investigated extensively. The purpose of the present study was to extend earlier investigations into the effect of tetracycline on phagocytosis of bacteria and yeast by human neutrophils. Reports on the effect of tetracycline on the function of leukocytes have been contradictory. In 1950 an engulfment-inhibiting effect was ascribed to chloratetracycline [1]. However, in a later report by other investigators, no such effect was demonstrated with tetracycline hydrochloride [2]. In more recent reports tetracycline hydrochloride has been shown to inhibit chemotaxis [3, 4] and maximal reduction of nitroblue tetrazolium dye (NBT) [5] by human leukocytes. In one study tetracyclines were shown to inhibit the bactericidal effect of serum, but not opsonization of bacteria [6].