Role of Beta-arrestin 2 downstream of dopamine receptors in the Basal Ganglia.
Role of Beta-arrestin 2 downstream of dopamine receptors in the Basal Ganglia.
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DOI：
10.3389/fnana.2011.00058
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发表时间：
2011
影响因子：
2.9
通讯作者：
Beaulieu JM
中科院分区：
文献类型：
--
作者：
Del'guidice T;Lemasson M;Beaulieu JM
多功能支架蛋白β-抑制蛋白（βArr）和G蛋白受体激酶参与了几种G蛋白偶联受体（GPCR）的脱敏。然而，抑制蛋白也可以独立于G蛋白而促进GPCR信号传导。本文就βArr在纹状体多巴胺受体功能调节中的作用作一综述。首先，我们目前在体内的证据支持这些蛋白质在调节多巴胺受体脱敏的作用。其次，我们提供了一个概述β Arr 2在调节D1和D2多巴胺受体下游的细胞外信号调节激酶/MAP激酶和Akt/GSK 3信号通路中的作用。此后，我们研究了β Arr介导的信号传导在用于治疗精神障碍的多巴胺能药物的作用中的可能参与。最后，我们集中在不同的潜在的细胞蛋白质的β Arr介导的信号调节，这可能有助于调节多巴胺的行为反应。总的来说，多巴胺受体下游βArr的细胞信号传导功能的鉴定强调了基底神经节中调节和介导细胞信号传导的交织机制的复杂性。了解这些机制可能会导致更好地理解这些结构在情绪调节中发挥的几种作用，并开发具有更好疗效的新精神活性药物。
Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases are involved in the desensitization of several G protein-coupled receptors (GPCR). However, arrestins can also contribute to GPCR signaling independently from G proteins. In this review, we focus on the role of βArr in the regulation of dopamine receptor functions in the striatum. First, we present in vivo evidence supporting a role for these proteins in the regulation of dopamine receptor desensitization. Second, we provide an overview of the roles of βArr2 in the regulation of extracellular-signal-regulated kinases/MAP kinases and Akt/GSK3 signaling pathways downstream of the D1 and D2 dopamine receptors. Thereafter, we examine the possible involvement of βArr-mediated signaling in the action of dopaminergic drugs used for the treatment of mental disorders. Finally, we focus on different potential cellular proteins regulated by βArr-mediated signaling which could contribute to the regulation of behavioral responses to dopamine. Overall, the identification of a cell signaling function for βArr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy.
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影响因子：
11.4
作者：
CADE, JFJ
通讯作者：
CADE, JFJ
DOI：
10.1073/pnas.96.15.8745
发表时间：
1999-07-20
影响因子：
11.1
作者：
Chalecka-Franaszek, E;Chuang, DM
通讯作者：
Chuang, DM
影响因子：
10.6
作者：
Alimohamad, H;Rajakumar, N;Rushlow, W
通讯作者：
Rushlow, W
影响因子：
4.7
作者：
Bychkov, Evgeny;Ahmed, M. Rafiuddin;Gurevich, Eugenia V.
通讯作者：
Gurevich, Eugenia V.
影响因子：
4.8
作者：
Ahn, SK;Shenoy, SK;Lefkowitz, RJ
通讯作者：
Lefkowitz, RJ