Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice
Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice
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人参皂苷Rg1对慢性束缚应激所致雄性小鼠学习记忆障碍的保护作用
DOI：
10.1016/j.pbb.2014.02.012
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发表时间：
2014-05-01
影响因子：
3.6
通讯作者：
Li, Weizu
中科院分区：
文献类型：
--
作者：
Wang, Yuchan;Kan, Hongwei;Li, Weizu
阿尔茨海默病（Alzheimer's disease，AD）是老年人的主要神经系统疾病之一。慢性应激可导致额叶皮质、海马等脑区的萎缩和功能障碍，在AD的发生和发展中起重要作用。目前，还没有有效的药物治疗方案来预防慢性应激诱导的学习和记忆障碍以及神经元损伤。人参皂苷Rg 1（Ginsenoside Rg 1，Rg 1）是人参中含量丰富的甾体皂苷。本研究探讨人参皂甙Rg 1对慢性束缚应激（CRS）所致小鼠学习记忆障碍的保护作用。我们的研究结果表明，人参皂甙Rg 1（5 mg/kg）对CRS诱导的Morris水迷宫学习记忆障碍有明显的保护作用。Rg 1（2，5 mg/kg）能减少小鼠额叶皮质和海马CA 1区ROS的产生，减轻神经元的氧化损伤。此外，Rg 1对NOX 2、p47 phox和RAC 1表达的抑制也参与了Rg 1的作用机制。本研究为人参皂苷Rg 1在慢性应激所致神经元氧化损伤中的临床应用提供了实验依据。(C)2014 Elsevier Inc. All rights reserved.
Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. Chronic stress, which can induce atrophy and functional impairments in several key brain areas such as the frontal cortex and hippocampus, plays an important role in the generation and progression of AD. Currently, there are no effective drug treatment options for preventing chronic stress induced learning and memory impairments and neuronal damage. Ginsenoside Rg1 (Rg1) is a steroidal saponin abundantly contained in ginseng. This study explored the neuroprotective effects of Rg1 on chronic restraint stress (CRS) induced learning and memory impairments in a mouse model. Our results showed that Rg1 (5 mg/kg) significantly protected against learning and memory impairments induced by CRS in a Morris water maze. Besides, Rg1 (2, 5 mg/kg) was able to decrease ROS generation and attenuate the neuronal oxidative damage in the frontal cortex and hippocampus CA1 in mice. Additionally, the inhibition of NOX2, p47phox and RAC1 expression is also involved in the action mechanisms of Rg1 in this experimental model. This study provided an experimental basis for the clinical application of Rg1 in chronic stress induced neuronal oxidative damage. (C) 2014 Elsevier Inc. All rights reserved.