Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Cytomegaloviruses: From Molecular Pathogenesis to Intervention
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巨细胞病毒：从分子发病机制到干预
DOI：
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发表时间：
2013
影响因子：
11.8
通讯作者：
J. Tang
中科院分区：
文献类型：
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作者：
J. Tang
许多卫生专业人员依靠期刊文章来跟上他们领域的进步，因为教科书在出版时通常已经过时1-2年，而且比偶尔从大学图书馆网站下载的PDF要贵得多。这两卷关于巨细胞病毒（CMV）的文本是昂贵的，引用了2012年之前的数据，但为应用新发现提供了坚实的基础。第一卷主要集中在CMV的基础科学和相关的动物实验;第二卷是针对临床读者，再次与相关的动物模型研究的章节。每一章读起来都像一篇简短的评论文章，很容易消化。这一领域的许多知名专家提供了内容，应该让读者放心。文本和参考风格易于阅读，图表和表格说明性强，很有帮助。这些书体积小巧，便于携带，也可以作为电子书下载。
第一卷对灵长类动物和小鼠CMV、CMV代谢组学、miRNA和蛋白质组学进行了深入的概述。大部分章节致力于病毒基因表达和功能以及病毒与人类宿主细胞的相互作用，描述免疫反应，病毒嗜性，进入，发病机制和潜伏期的方面。第一卷中使用的术语是专门的，对于不从事这些领域工作的读者来说可能很难。
第二卷包括基本的临床背景：CMV感染的流行病学在怀孕期间，CMV感染的固体和骨髓移植，CMV治疗和耐药性，诊断方法和疫苗的发展。额外的章节描述了宿主对CMV感染的免疫反应，以及特定目标（如胎盘）的感染机制。
两卷书中的章节都写得很详细，很清楚;编辑们在保持这一标准方面值得赞扬。然而，额外的细节和讨论（即，关于移植患者CMV PCR监测的替代靶点（如pp 65抗原和pp 67 mRNA与DNA）的利弊）将是有帮助的。此外，一个深入的章节，在各种临床情况下的CMV再感染或重复感染菌株的特点将是有用的;这样的菌株是经常提到整个临床文本没有描述。也许在临床方面的一个令人惊讶的遗漏是一章比较和对比移植患者CMV感染治疗的各种临床指南;这将突出如何解释已发表数据的差异。
第II.23章，与巨细胞病毒相关的假定疾病：一项重要调查，探讨了CMV作为特定临床综合征（包括多形性胶质母细胞瘤、心血管疾病）病原体的可能作用，以及CMV可能在免疫衰老中发挥的作用。这使得引人入胜和教育阅读，特别是在作者如何梳理出相关（和不相关）的证据，支持和反对这些潜在的病因作用。
价格相当可观，尽管这两卷可以单独购买（http：//www.horizonpress.com/hsp/cnentary/cmv2/cmv2-vol1-vol2.html）。作为一名医学临床病毒学家，我发现第二卷是一个有用的参考文本。那些从事CMV基础病毒学研究的人可能会认为第一卷是他们图书馆的一个有用的补充。这些卷给出了全面的，但简明扼要的概述了CMV的许多方面的知识的现状，并详细到足以满足大多数读者。
Many health professionals rely on journal articles to keep up with advances in their field because textbooks are often 1–2 years out of date by the time they come to press, and are far more expensive than the occasional PDF downloaded from a university library Web site. This 2-volume text on cytomegalovirus (CMV) is costly and cites data from before 2012, but provides a solid foundation on which to apply new findings. Volume I is mainly focused on the basic science of and related animal experiments on CMV; volume II is aimed at the clinical reader, again with chapters on relevant animal model studies. Each chapter reads as a short review article, and is easily digestible. Many well-recognized experts in this field contributed content, which should be reassuring to the reader. The text and referencing style are easy to read and the figures and tables are illustrative and helpful. The volumes come in a compact size, making them convenient to carry, and also are downloadable as eBooks.
Volume I gives in-depth overviews of primate and murine CMVs, CMV metabolomics, miRNAs, and proteomics. Most of the chapters are dedicated to viral gene expression and function and virus interaction with human host cells, describing immune response, aspects of viral tropism, entry, pathogenesis, and latency. The terminology used in Volume I is specialized and may be difficult for readers who do not work in these fields.
Volume II covers essential clinical background: the epidemiology of CMV infections in pregnancy, CMV infections in solid and bone marrow transplants, CMV therapy and drug resistance, diagnostic methods, and vaccine development. Additional chapters describe the host immune response to CMV infection, and mechanisms of infection in specific targets, such as the placenta.
Chapters in both volumes are detailed and clearly written; the editors are to be commended on maintaining this standard. However, additional detail and discussion (i.e., pros and cons) about alternative targets for CMV PCR monitoring of transplant patients, such as pp65 antigen and pp67 mRNA versus DNA, would have been helpful. Also, an in-depth chapter on the characteristics of reinfecting or superinfecting strains of CMV in various clinical situations would be useful; such strains are frequently referred to without description throughout the clinical text. Perhaps one surprising omission on the clinical side is a chapter comparing and contrasting the various clinical guidelines for the treatment of CMV infections in transplant patients; this would highlight differences in how published data are interpreted.
Chapter II.23, Putative Disease Associations with Cytomegalovirus: a Critical Survey, explores the possible role of CMV as an etiologic agent for specific clinical syndromes, including glioblastomamultiforme, cardiovascular disease, and the role that CMV may play in immunosenescence. This makes fascinating and educational reading, especially in how the authors tease out the relevant (and irrelevant) evidence for and against these potential etiologic roles.
The price tag is considerable, although the 2 volumes can be purchased separately (http://www.horizonpress.com/hsp/supplementary/cmv2/cmv2-vol1-vol2.html). As a medical–clinical virologist, I find Volume II to be a useful reference text. Those working on the basic virology of CMV may consider Volume I a useful addition to their libraries. These volumes give comprehensive, yet succinct overviews of the current state of knowledge of many aspects of CMV and are detailed enough to satisfy most readers.