Meta-analysis, funnel plots and sensitivity analysis.
Meta-analysis, funnel plots and sensitivity analysis.
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DOI：
10.1093/biostatistics/1.3.247
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发表时间：
2000-09-01
期刊：
影响因子：
--
通讯作者：
Shi, J Q
中科院分区：
文献类型：
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作者：
Copas, J;Shi, J Q
发表偏倚是荟萃分析（或系统评价）中的一个主要问题，也许是最主要的问题。如果结果是“显著的”，而不是负面的或不确定的，那么小型研究更有可能被发表，因此可供审查的研究偏向于那些具有积极结果的研究。如果不做出不可检验的假设，就不可能纠正这种偏差。本文提出了一种基于漏斗图拟合模型的敏感性分析方法。文中还讨论了一些实例。
Publication bias is a major problem, perhaps the major problem, in meta-analysis (or systematic reviews). Small studies are more likely to be published if their results are 'significant' than if their results are negative or inconclusive, and so the studies available for review are biased in favour of those with positive outcomes. Correcting for this bias is not possible without making untestable assumptions. In this paper, a sensitivity analysis is suggested which is based on fitting a model to the funnel plot. Some examples are discussed.