Safety and efficacy of topical mitomycin C in myringotomy patency.
Safety and efficacy of topical mitomycin C in myringotomy patency.
复制标题
局部丝裂霉素 C 在鼓膜切开术通畅中的安全性和有效性。
DOI：
10.1067/mhn.2001.114255
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Gomez-Marin,O
中科院分区：
文献类型：
--
作者：
Jassir,D;Buchman,CA;Gomez-Marin,O
目的：开发一种替代方法，延长中耳通气局部丝裂霉素C。研究设计和设置：20只豚鼠与正常耳朵进行了双侧鼓膜切开术使用氩激光。鼓膜切开术后，局部应用丝裂霉素C（0.4 mg/mL）或生理盐水纱布。监测包括otomicroscopy和畸变产物otoacoustic emissions.RESULTS：鼓膜切开术前，所有的鼓膜是完整的，和畸变产物耳声发射是可测量的。鼓膜切开术后，与丝裂霉素C治疗的鼓膜切开术的100%相比，生理盐水治疗的鼓膜切开术在第7天没有（0%）通畅。在第42天，19例丝裂霉素治疗的鼓膜切开术中有10例（52.6%）保持通畅，14例中有4例（28.6%）在第131天保持通畅。5只（13.1%）耳发生化脓性耳炎; 3只接受丝裂霉素C治疗，2只接受生理盐水治疗。畸变产物耳声发射测试没有记录任何证据的otototoxic.CONCLUSION：局部丝裂霉素C似乎是安全和有效的，在延长鼓膜切开术通畅的豚鼠的持续时间。SIGNIFICANCE：丝裂霉素C可能是有用的，作为一种辅助预防鼓膜切开术关闭。
OBJECTIVE:To develop an alternative method for prolonged middle ear ventilation using topical mitomycin C.STUDY DESIGN AND SETTING:Twenty guinea pigs with normal ears had bilateral myringotomies performed using the argon laser. After myringotomy, either mitomycin C (0.4 mg/mL) or saline pledgets were applied topically. Monitoring consisted of otomicroscopy and distortion-product otoacoustic emissions.RESULTS:Before myringotomy, all tympanic membranes were intact, and distortion-product otoacoustic emissions were measurable. After myringotomy, none (0%) of the saline-treated myringotomies were patent at day 7 as compared with 100% of the mitomycin C-treated myringotomies. At day 42, 10 (52.6%) of 19 mitomycin-treated myringotomies remained patent and 4 (28.6%) of 14 were patent at 131 days. Five (13.1%) ears developed purulent otorrhea; 3 were mitomycin C-treated and 2 were treated with saline solution. Distortion-product otoacoustic emissions testing did not document any evidence of ototoxicity.CONCLUSION:Topical mitomycin C appears to be safe and effective at prolonging the duration of myringotomy patency in the guinea pig.SIGNIFICANCE:Mitomycin C may be useful as an adjunct for preventing myringotomy closure.