Discordant effect of interferon on natural killer activity and tumor cell sensitivity to lysis in hairy cell leukemia.

Discordant effect of interferon on natural killer activity and tumor cell sensitivity to lysis in hairy cell leukemia.
复制标题

干扰素对毛细胞白血病自然杀伤活性和肿瘤细胞对裂解的敏感性的不一致作用。

DOI：
--
复制
发表时间：
1988
期刊：
Blood
影响因子：
20.3
通讯作者：
P. Froom
P. Froom
中科院分区：
医学1区
文献类型：
--
作者：
N. Lahat;E. Aghai;A. Kotler;A. Kinarty;E. Sobel;N. Gruener;P. Froom

文献摘要

参考文献

被引文献

相似文献

我们研究了 α-干扰素 (IFN) 和白细胞介素 2 (IL-2) 对两名毛细胞白血病 (HCL) 患者富含自然杀伤 (NK) 的组分和自体肿瘤细胞的作用。向富含 NK 的组分中添加 IFN 或 IL-2 导致针对自体肿瘤细胞的 NK 活性显着增加。如果目标毛细胞 (HC) 与 IFN 或 IL-2 预孵育，则这种刺激作用会被阻断。用抗 Tac 抗体预处理 HC 完全阻止了 IL-2 的阻断作用，并部分阻止了 IFN 的阻断作用。一名患者接受重组α-c-IFN 治疗。 2个月后，外周血中的HC数量急剧减少，同时IFN对患者HC的NK裂解的保护作用丧失。针对自体肿瘤细胞的 NK 活性与针对 K562 细胞系的 NK 活性相关性较差。我们得出的结论是，IFN 和 IL-2 对 NK 活性和 HC 对裂解的敏感性具有不一致的影响。 Tac 受体似乎在这种敏感性中发挥了作用。将 NK 活性对 K562 细胞的影响外推至对 HC 靶标的影响时应谨慎。
We studied the action of alpha-interferon (IFN) and interleukin-2 (IL-2) on natural killer (NK)-rich fractions and autologous tumor cells from two patients with hairy cell leukemia (HCL). The addition of IFN or IL-2 to the NK-rich fractions resulted in a significant increase in NK activity against the autologous tumor cells. This stimulatory effect was blocked if the target hairy cells (HCs) were preincubated with either IFN or IL-2. Pretreatment of the HCs with anti-Tac antibody entirely prevented the blocking effect of IL-2 and partially the blocking effect of IFN. One patient was treated with recombinant alpha c-IFN. After 2 months there was a dramatic reduction in the number of HCs in the peripheral blood coincident with the loss of the protection effect of IFN against NK lysis of the patient's HCs. NK activity against autologous tumor cells correlated poorly with that against the K562 cell line. We conclude that there is a discordant effect of IFN and IL-2 on NK activity and HC sensitivity to lysis. The Tac receptor appears to play a role in this sensitivity. Caution should be exercised in extrapolating the effects of NK activity against K562 cells to those on HC targets.
Studies on the mechanism of natural killer cell-mediated cytotoxicity. IV. Interferon-induced inhibition of NK target cell susceptibility to lysis is due to a defect in their ability to stimulate release of natural killer cytotoxic factors (NKCF).
自然杀伤细胞介导的细胞毒作用机制的研究。
DOI： --
发表时间： 1983
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者：
Wright,SC;Bonavida,B
通讯作者： Bonavida,B
Natural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity.
毛细胞白血病中的自然杀伤淋巴细胞：存在功能活性缺陷的表型可识别细胞。
DOI： --
发表时间： 1985
期刊： Experimental hematology
影响因子： 2.6
作者：
Smith,BR;Rosenthal,DS;Ault,KA
通讯作者： Ault,KA