Adrenocortical function in critically ill patients 24 h after a single dose of etomidate
Adrenocortical function in critically ill patients 24 h after a single dose of etomidate
复制标题
危重患者单剂量依托咪酯24小时后肾上腺皮质功能
作者：
A. Absalom;D. Pledger;A. Kong
我们在一项随机对照临床试验中比较了单剂量依托咪酯和硫喷妥对肾上腺皮质功能的影响，该试验涉及35名需要全身麻醉的危重患者。在麻醉诱导前，取基线血皮质醇样本。24小时后，我们进行了简短的促肾上腺皮质激素刺激试验。在研究期间，没有患者出现低皮质醇水平（< 160 nmol.l−1）。两组患者ACTH前和ACTH后的皮质醇基线水平相似。然而，在依托咪酯组中，有更多的患者ACTH刺激的皮质醇增量< 200 nmol. 1−1。这些发现的临床意义尚不清楚，但我们得出结论，在危重患者中，单剂量依托咪酯可能干扰皮质醇合成至少24小时。
We compared the effects of single doses of etomidate and thiopentone on adrenocortical function in a randomised controlled clinical trial involving 35 critically ill patients who needed a general anaesthetic. Just before induction of anaesthesia, a baseline blood cortisol sample was taken. Twenty‐four hours later we performed a short adrenocorticotrophic hormone stimulation test. No patient had a low cortisol level (< 160 nmol.l−1) at any time during the study. Baseline, pre‐ACTH and post‐ACTH cortisol levels were similar in the two groups. However, significantly more patients in the etomidate group had an ACTH‐stimulated cortisol increment < 200 nmol.l−1. The clinical significance of these findings is not clear, but we conclude that single doses of etomidate may interfere with cortisol synthesis for at least 24 h in the critically ill.
影响因子：
158.5
作者：
WAGNER, RL;WHITE, PF;FELDMAN, D
通讯作者：
FELDMAN, D
临床回顾 62：肾上腺功能不全的实验室评估。
DOI：
10.1210/jcem.79.4.7962298
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Grinspoon,SK;Biller,BM
通讯作者：
Biller,BM
使用地塞米松-促肾上腺皮质激素测试来评估垂体手术后是否需要继续糖皮质激素替代治疗。
DOI：
10.1210/jcem-60-5-1012
发表时间：
1985
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Beyer,HS;Bantle,JP;Mariash,CN;Steffes,MW;Seljeskog,EL;Oppenheimer,JH
通讯作者：
Oppenheimer,JH