Effects of sericin on heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats
Effects of sericin on heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats
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DOI：
10.3969/j.issn.1673-5374.2011.06.004
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发表时间：
2011-02-25
影响因子：
6.1
通讯作者：
Xue, Jingfeng
中科院分区：
文献类型：
--
作者：
Chen, Zhihong;He, Yaqiang;Xue, Jingfeng
以前的研究表明，丝胶有效地降低血糖，保护胰岛细胞，以及性腺和肾脏。然而，丝胶是否能改善糖尿病引起的中枢神经系统的结构和功能问题仍然知之甚少。采用链脲佐菌素腹腔注射法制备大鼠2型糖尿病模型。本研究观察了糖尿病大鼠海马区和大脑皮层的组织学变化，以及血红素加氧酶-1的表达，并探讨了丝胶对中枢神经系统的影响。连续35天灌胃丝胶2.4g/kg可减轻大鼠海马神经细胞和大脑皮层神经细胞的病理损伤。丝胶治疗后糖尿病大鼠海马区和大脑皮层中的血红素氧合酶-1蛋白和mRNA的表达均降低。结果提示，丝胶通过降低糖尿病后高表达的血红素加氧酶-1对神经系统起到保护作用。
Previous studies have demonstrated that sericin effectively reduces blood glucose, and protects islet cells, as well as the gonads and kidneys. However, whether sericin improves diabetes mellitus-induced structural and functional problems in the central nervous system remains poorly understood. Rat models of type 2 diabetes mellitus were established by intraperitoneal injection of streptozotocin. The present study observed histological changes in the hippocampus and cerebral cortex, as well as heme oxygenase-1 expression, and explored sericin effects on the central nervous system in diabetic rats. Pathological damage to neural cells in the rat hippocampus and cerebral cortex was relieved following intragastric administration of sericin at a dose of 2.4 g/kg for 35 consecutive days. Heme oxygenase-1 protein and mRNA expressions were decreased in the hippocampus and cerebral cortex of diabetes mellitus rats after sericin treatment. The results suggest that sericin plays a protective effect on the nervous system by decreasing the high expression of heme oxygenase-1 following diabetes mellitus.