Focus on PTEN Regulation.
Focus on PTEN Regulation.
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DOI：
10.3389/fonc.2015.00166
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发表时间：
2015
影响因子：
4.7
通讯作者：
Papakonstanti EA
中科院分区：
文献类型：
--
作者：
Bermúdez Brito M;Goulielmaki E;Papakonstanti EA
10号染色体上的磷酸酶和张力蛋白同源物（PTEN）作为肿瘤抑制剂的作用长期以来归因于其针对PI（3，4，5）P3（I类PI 3Ks的磷脂产物）的脂质磷酸酶活性。除了其作为质膜上的脂质磷酸酶的传统作用外，大量数据表明，PTEN可以独立于其磷酸酶活性发挥作用，并且PTEN也存在于细胞核、细胞质细胞器和细胞外并发挥作用。越来越多的证据揭示了PTEN的多种生理功能，这些功能伴随着其表达和活性的复杂调节。PTEN的水平和功能在转录、转录后和转录后都受到调节。PTEN也对通过其相互作用蛋白及其定位的调节敏感。在此，我们总结了目前的知识机制，调节表达和酶活性的PTEN及其在人类疾病中的作用。
The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P3, the phospholipid product of the class I PI3Ks. Besides its traditional role as a lipid phosphatase at the plasma membrane, a wealth of data has shown that PTEN can function independently of its phosphatase activity and that PTEN also exists and plays a role in the nucleus, in cytoplasmic organelles, and extracellularly. Accumulating evidence has shed light on diverse physiological functions of PTEN, which are accompanied by a complex regulation of its expression and activity. PTEN levels and function are regulated transcriptionally, post-transcriptionally, and post-translationally. PTEN is also sensitive to regulation by its interacting proteins and its localization. Herein, we summarize the current knowledge on mechanisms that regulate the expression and enzymatic activity of PTEN and its role in human diseases.