Animal Models of Acute and Chronic Inflammatory and Nociceptive Pain
Animal Models of Acute and Chronic Inflammatory and Nociceptive Pain
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DOI：
10.1007/978-1-60327-323-7_4
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发表时间：
2010-01-01
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影响因子：
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通讯作者：
Jarvis, Michael F.
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文献类型：
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作者：
Boyce-Rustay, Janel M.;Honore, Prisca;Jarvis, Michael F.
为了便于研究疼痛传递和新型镇痛化合物的特性，一系列实验动物疼痛模型主要是在啮齿动物中建立的。在这些临床前模型中，伤害性疼痛可以通过自发行为和诱发行为来测量。急性疼痛（几秒到几小时）可以更容易地测量，尽管仍然有一些困难，通过自发行为（如舔，退缩等恶意行为）或刺激受伤的爪子。慢性疼痛（持续至少几天）最容易通过诱发刺激（热刺激、机械刺激、化学刺激）来测量。诱发性疼痛的实验测量有很好的特征，与临床诊断方法相似。本章将重点介绍炎症性和伤害性疼痛的啮齿动物模型，这些模型在我们的实验室中用于鉴定药物发现中的新型抗伤害性化合物。
To facilitate the study of pain transmission and the characterization of novel analgesic compounds, an array of experimental animal pain models has been developed mainly in rodents. In these preclinical models, nociceptive pain can be measured by both spontaneous and evoked behaviors. Acute pain (seconds to hours) can be more easily measured, albeit still with some difficulty, by spontaneous behaviors (nocifensive behaviors such as licking, flinching), or by stimulation of the injured paw. Chronic pain (lasting at least several days) is most readily measured by evoked stimulation (thermal, mechanical, chemical). Experimental measures of evoked pain are well characterized and are analogous to clinical diagnostic methods. This chapter will focus on rodent models of inflammatory and nociceptive pain that are most used in our laboratory for identification of novel antinociceptive compounds in drug discovery.