Field cancerization in the colon: a role for aberrant DNA methylation?
Field cancerization in the colon: a role for aberrant DNA methylation?
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DOI：
10.1093/gastro/got039
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发表时间：
2014-02
影响因子：
3.6
通讯作者：
Grady WM
中科院分区：
文献类型：
--
作者：
Luo Y;Yu M;Grady WM
结直肠癌是全球第三大常见癌症，并且继发于正常结肠细胞中遗传和表观遗传改变的进行性积累，这导致息肉到癌症进展序列。已知具有结肠腺瘤或结肠癌个人病史的个体发生异时性结肠肿瘤的风险增加。这种风险增加的一种解释可能是实地癌变，这是一种器官中组织学正常组织准备进行转化的现象。表观遗传学改变似乎是有前途的标记领域癌变。在这篇综述中，我们讨论了在结肠领域的癌变和数据支持使用甲基化DNA作为这种现象的生物标志物。
Colorectal cancer is the third most common cancer worldwide and arises secondary to the progressive accumulation of genetic and epigenetic alterations in normal colon cells, which results in a polyp-to-cancer progression sequence. It is known that individuals with a personal history of colon adenomas or cancer are at increased risk for metachronous colon neoplasms. One explanation for this increased risk could be field cancerization, which is a phenomenon in which the histologically normal tissue in an organ is primed to undergo transformation. Epigenetic alterations appear to be promising markers for field cancerization. In this review, we discuss field cancerization in the colon and the data supporting the use of methylated DNA as a biomarker for this phenomenon.