FLUORINE COMPOUNDS IN ANAESTHESIA (6) - EXAMINATION OF 14 HEAVILY HALOGENATED RING COMPOUNDS
FLUORINE COMPOUNDS IN ANAESTHESIA (6) - EXAMINATION OF 14 HEAVILY HALOGENATED RING COMPOUNDS
复制标题
DOI：
10.1111/j.1365-2044.1964.tb00364.x
复制
发表时间：
1964-01-01
期刊：
影响因子：
10.7
通讯作者：
BRACKEN, A
中科院分区：
文献类型：
--
作者：
BURNS, THS;HALL, JM;BRACKEN, A
所有这些物质都是在伯明翰大学化学系Stacey教授和Tatlow教授的指导下制备和提纯的。实验工作由H.麦克斯韦尔小姐、J.罗伊兰斯先生和T. W.里明顿先生进行。这些化合物的结构和沸点的详细情况载于构成本报告主体的表格中。这表明，目前没有一种化合物有足够的前景作为麻醉剂来证明进一步的研究是合理的。它们是惰性的，易燃的，或者有直接的毒性作用。然而，人们认为，尽管结果是否定的，但却很重要，因为在这些调查中出现了一些有趣的事实。五氟苯和六氟四氢吡喃（六氟环氧己烷）是无明显毒性症状的麻醉剂。单甲氧基七氟环戊烯1，h: 2， H-六氟环丁烷和1，h: 3， H-八氟环戊烷具有合成性能，但也有各种不期望的特性。全氟甲基环己烷、全氟二甲基环己烷和全氟溴苯基本上是惰性的。其余的化合物表现出不同程度的毒性。除第40号化合物因样品不足而未进行测试外，其余化合物均可在氧气中燃烧，部分可在空气中燃烧。下列物质与碱石灰反应：十氟环己烯；1、H: 3、H-辛氟环戊烷；1、H: 2、H-六氟环丁烷。
All these substances were prepared and purdied in the Chemistry Department, Birmingham University, under the direction of Professor Stacey and Professor Tatlow. The experimental work was carried out by Miss H. Maxwell, Mr J. Roylance and Mr T. W. Rimmington. Details of the structures and boiling points of the compounds are given in the table forming the main body of this report. It is suggested that none of the compounds is sufficiently promising as an anresthetic to justify further investigation at this time. They were inert, flammable, or had immediate toxic effects. It is felt, however, that the results-although negative-are important, since several interesting facts emerged during these investigations. Pentafluorobenzene and hexafluorotetrahydropyran (hexafluoroepoxyhexane) were anmthetics devoid of obvious toxic symptoms. Monomethoxyheptafluorocyclopentene 1, H: 2, H-hexafluorocyclobutane and 1, H: 3, H-octafluorocyclopentane had anathetic properties, but also various undesirable features. Perfluoromethylcyclohexane, perfluorodimethylcyclohexane and perfluorobromobenzene were substantially inert. The rest of the compounds showed varying degrees of toxicity.All the compounds except No. 40, which was not tested, because of shortage of sample, could be made to burn in oxygen and some in air. The following substances reacted with soda lime: decafluorocyclohexene; 1, H: 3, H-octafluorocyclopentane; and 1, H: 2, H-hexafluorocyclobutane.